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| Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats | |
Li, Xinpeng1,3 ; Wang, Jing1,2; Zhang, Hong1,2; Zhang, Quanbin1,2
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| 2017-02-01 | |
| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 卷号 | 95页码:132-137 |
| 文章类型 | Article |
| 摘要 | We investigated the renal protective effect of low-molecular-weight sulfated polysaccharide (LMWSP) fractions extracted from Laminaria japonica on glycerol-induced acute kidney injury (AKI) in rats. Glycerol treatment significantly increased serum creatinine (SCr) and blood urea nitrogen (BUN) levels. Intraperitoneal injection of LMWSP fractions markedly decreased SCr and BUN levels and reduced renal swelling. The fraction of 1.0 M NaCl displayed the best renal protective effect of all fractions in attenuating AKI and maintaining blood glucose. (C) 2016 Elsevier B.V. All rights reserved. |
| 关键词 | Acute Kidney Injury Low-molecular-weight Sulfated Polysaccharide Renal Protective Effect |
| DOI | 10.1016/j.ijbiomac.2016.11.051 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000392903000018 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/136303 |
| 专题 | 实验海洋生物学重点实验室 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Beijing 100864, Peoples R China 2.Qjngdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Li, Xinpeng,Wang, Jing,Zhang, Hong,et al. Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,95:132-137. |
| APA | Li, Xinpeng,Wang, Jing,Zhang, Hong,&Zhang, Quanbin.(2017).Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,95,132-137. |
| MLA | Li, Xinpeng,et al."Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 95(2017):132-137. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Renoprotective effec（1033KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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