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Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats
Li, Xinpeng1,3; Wang, Jing1,2; Zhang, Hong1,2; Zhang, Quanbin1,2
2017-02-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume95Pages:132-137
SubtypeArticle
AbstractWe investigated the renal protective effect of low-molecular-weight sulfated polysaccharide (LMWSP) fractions extracted from Laminaria japonica on glycerol-induced acute kidney injury (AKI) in rats. Glycerol treatment significantly increased serum creatinine (SCr) and blood urea nitrogen (BUN) levels. Intraperitoneal injection of LMWSP fractions markedly decreased SCr and BUN levels and reduced renal swelling. The fraction of 1.0 M NaCl displayed the best renal protective effect of all fractions in attenuating AKI and maintaining blood glucose. (C) 2016 Elsevier B.V. All rights reserved.
KeywordAcute Kidney Injury Low-molecular-weight Sulfated Polysaccharide Renal Protective Effect
DOI10.1016/j.ijbiomac.2016.11.051
Indexed BySCI
Language英语
WOS IDWOS:000392903000018
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136303
Collection实验海洋生物学重点实验室
海洋生物技术研发中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Beijing 100864, Peoples R China
2.Qjngdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
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Li, Xinpeng,Wang, Jing,Zhang, Hong,et al. Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,95:132-137.
APA Li, Xinpeng,Wang, Jing,Zhang, Hong,&Zhang, Quanbin.(2017).Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,95,132-137.
MLA Li, Xinpeng,et al."Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 95(2017):132-137.
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