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Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats
Li, Xinpeng1,3; Wang, Jing1,2; Zhang, Hong1,2; Zhang, Quanbin1,2
2017-02-01
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号95页码:132-137
文章类型Article
摘要We investigated the renal protective effect of low-molecular-weight sulfated polysaccharide (LMWSP) fractions extracted from Laminaria japonica on glycerol-induced acute kidney injury (AKI) in rats. Glycerol treatment significantly increased serum creatinine (SCr) and blood urea nitrogen (BUN) levels. Intraperitoneal injection of LMWSP fractions markedly decreased SCr and BUN levels and reduced renal swelling. The fraction of 1.0 M NaCl displayed the best renal protective effect of all fractions in attenuating AKI and maintaining blood glucose. (C) 2016 Elsevier B.V. All rights reserved.
关键词Acute Kidney Injury Low-molecular-weight Sulfated Polysaccharide Renal Protective Effect
DOI10.1016/j.ijbiomac.2016.11.051
收录类别SCI
语种英语
WOS记录号WOS:000392903000018
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136303
专题实验海洋生物学重点实验室
海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Beijing 100864, Peoples R China
2.Qjngdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Li, Xinpeng,Wang, Jing,Zhang, Hong,et al. Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,95:132-137.
APA Li, Xinpeng,Wang, Jing,Zhang, Hong,&Zhang, Quanbin.(2017).Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,95,132-137.
MLA Li, Xinpeng,et al."Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 95(2017):132-137.
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