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Gene set based association analyses for the WSSV resistance of Pacific white shrimp Litopenaeus vannamei
Yu, Yang1; Liu, Jingwen1,2; Li, Fuhua1,3; Zhang, Xiaojun1; Zhang, Chengsong1; Xiang, Jianhai1,3
2017-01-17
发表期刊SCIENTIFIC REPORTS
卷号7
文章类型Article
摘要White Spot Syndrome Virus (WSSV) is regarded as a virus with the strongest pathogenicity to shrimp. For the threshold trait such as disease resistance, marker assisted selection (MAS) was considered to be a more effective approach. In the present study, association analyses of single nucleotide polymorphisms (SNPs) located in a set of immune related genes were conducted to identify markers associated with WSSV resistance. SNPs were detected by bioinformatics analysis on RNA sequencing data generated by Illimina sequencing platform and Roche 454 sequencing technology. A total of 681 SNPs located in the exons of immune related genes were selected as candidate SNPs. Among these SNPs, 77 loci were genotyped in WSSV susceptible group and resistant group. Association analysis was performed based on logistic regression method under an additive and dominance model in GenABEL package. As a result, five SNPs showed associations with WSSV resistance at a significant level of 0.05. Besides, SNP-SNP interaction analysis was conducted. The combination of SNP loci in TRAF6, Cu/Zn SOD and nLvALF2 exhibited a significant effect on the WSSV resistance of shrimp. Gene expression analysis revealed that these SNPs might influence the expression of these immune-related genes. This study provides a useful method for performing MAS in shrimp.
DOI10.1038/srep40549
收录类别SCI
语种英语
WOS记录号WOS:000391939100001
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136289
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
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Yu, Yang,Liu, Jingwen,Li, Fuhua,et al. Gene set based association analyses for the WSSV resistance of Pacific white shrimp Litopenaeus vannamei[J]. SCIENTIFIC REPORTS,2017,7.
APA Yu, Yang,Liu, Jingwen,Li, Fuhua,Zhang, Xiaojun,Zhang, Chengsong,&Xiang, Jianhai.(2017).Gene set based association analyses for the WSSV resistance of Pacific white shrimp Litopenaeus vannamei.SCIENTIFIC REPORTS,7.
MLA Yu, Yang,et al."Gene set based association analyses for the WSSV resistance of Pacific white shrimp Litopenaeus vannamei".SCIENTIFIC REPORTS 7(2017).
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