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Monomer composition of chitooligosaccharides obtained by different degradation methods and their effects on immunomodulatory activities
Xing, Ronge1,2; Liu, Yongliang1,2,3; Li, Kecheng1,2; Yu, Huahua1,2; Liu, Song1,2; Yang, Yue1,2; Chen, Xiaolin1,2; Li, Pengcheng1,2
2017-02-10
发表期刊CARBOHYDRATE POLYMERS
卷号157页码:1288-1297
文章类型Article
摘要Three kinds of chitooligosaccharides were prepared using traditional (ZCOS), microwave irradiation (WCOS), and enzymatic hydrolysis (YCOS), and their monomer compositions and in vitro and in vivo immunomodulatory activities were determined. ZCOS was mainly comprised of disaccharides and trisaccharides; WCOS was mainly comprised of disaccharides to hexasaccharides with or without acetyl groups; and YCOS was mainly comprised of trisaccharides to pentasaccharides without acetyl groups. Differences in monomer composition and acetyl groups affected their immunomodulatory activities. Chitooligosaccharides degraded by different methods: all significantly stimulated the immune system by acting through cellular and humoral immunities. WCOS, obtained by microwave irradiation, had the best immunomodulatory activity. It significantly increased the spleen index and significantly stimulated delayed-type hypersensitivity compared the other two chitooligosaccharides. These activities might have been the result of the hexamer and acetyl groups of WCOS. (C) 2016 Published by Elsevier Ltd.
关键词Chitooligosaccharide Degradation Methods Monomer Composition Immunomodulatory Activities Chitosan
DOI10.1016/j.carbpol.2016.11.001
收录类别SCI
语种英语
WOS记录号WOS:000391896800143
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136279
专题海洋生物技术研发中心
海洋环境工程技术研究发展中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Beijing 100864, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Beijing 100864, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Xing, Ronge,Liu, Yongliang,Li, Kecheng,et al. Monomer composition of chitooligosaccharides obtained by different degradation methods and their effects on immunomodulatory activities[J]. CARBOHYDRATE POLYMERS,2017,157:1288-1297.
APA Xing, Ronge.,Liu, Yongliang.,Li, Kecheng.,Yu, Huahua.,Liu, Song.,...&Li, Pengcheng.(2017).Monomer composition of chitooligosaccharides obtained by different degradation methods and their effects on immunomodulatory activities.CARBOHYDRATE POLYMERS,157,1288-1297.
MLA Xing, Ronge,et al."Monomer composition of chitooligosaccharides obtained by different degradation methods and their effects on immunomodulatory activities".CARBOHYDRATE POLYMERS 157(2017):1288-1297.
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