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Monomer composition of chitooligosaccharides obtained by different degradation methods and their effects on immunomodulatory activities
Xing, Ronge1,2; Liu, Yongliang1,2,3; Li, Kecheng1,2; Yu, Huahua1,2; Liu, Song1,2; Yang, Yue1,2; Chen, Xiaolin1,2; Li, Pengcheng1,2
2017-02-10
Source PublicationCARBOHYDRATE POLYMERS
Volume157Pages:1288-1297
SubtypeArticle
AbstractThree kinds of chitooligosaccharides were prepared using traditional (ZCOS), microwave irradiation (WCOS), and enzymatic hydrolysis (YCOS), and their monomer compositions and in vitro and in vivo immunomodulatory activities were determined. ZCOS was mainly comprised of disaccharides and trisaccharides; WCOS was mainly comprised of disaccharides to hexasaccharides with or without acetyl groups; and YCOS was mainly comprised of trisaccharides to pentasaccharides without acetyl groups. Differences in monomer composition and acetyl groups affected their immunomodulatory activities. Chitooligosaccharides degraded by different methods: all significantly stimulated the immune system by acting through cellular and humoral immunities. WCOS, obtained by microwave irradiation, had the best immunomodulatory activity. It significantly increased the spleen index and significantly stimulated delayed-type hypersensitivity compared the other two chitooligosaccharides. These activities might have been the result of the hexamer and acetyl groups of WCOS. (C) 2016 Published by Elsevier Ltd.
KeywordChitooligosaccharide Degradation Methods Monomer Composition Immunomodulatory Activities Chitosan
DOI10.1016/j.carbpol.2016.11.001
Indexed BySCI
Language英语
WOS IDWOS:000391896800143
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136279
Collection海洋生物技术研发中心
海洋环境工程技术研究发展中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Beijing 100864, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Beijing 100864, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
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Xing, Ronge,Liu, Yongliang,Li, Kecheng,et al. Monomer composition of chitooligosaccharides obtained by different degradation methods and their effects on immunomodulatory activities[J]. CARBOHYDRATE POLYMERS,2017,157:1288-1297.
APA Xing, Ronge.,Liu, Yongliang.,Li, Kecheng.,Yu, Huahua.,Liu, Song.,...&Li, Pengcheng.(2017).Monomer composition of chitooligosaccharides obtained by different degradation methods and their effects on immunomodulatory activities.CARBOHYDRATE POLYMERS,157,1288-1297.
MLA Xing, Ronge,et al."Monomer composition of chitooligosaccharides obtained by different degradation methods and their effects on immunomodulatory activities".CARBOHYDRATE POLYMERS 157(2017):1288-1297.
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