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Tongue sole (Cynoglossus semilaevis) CD59: A complement inhibitor that binds bacterial cells and promotes bacterial escape from the killing of fish serum
Sui, Zhi-hai1,2,3; Li, Mo-fei1,2; Sun, Li1,2
2016-11-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
Volume58Pages:442-448
SubtypeArticle
AbstractCD59 is a complement regulatory protein that inhibits the formation of membrane attack complex of complement. In this study, we examined the expression and activity of tongue sole (Cynoglossus semilaevis) CD59 (CsCD59). CsCD59 possesses the conserved structural features of CD59 and shares 33%-46% sequence identities with other fish CD59. Expression of CsCD59 was high in liver, spleen, and muscle, and was stimulated by infection of bacterial pathogens. Recombinant CsCD59 (rCsCD59) exhibited an apparent inhibition effect on the activation of tongue sole serum complement. ELISA and microscopy detected binding of rCsCD59 to a number of Gram-negative and Gram-positive bacteria. Interaction with rCsCD59 did not affect bacterial viability but significantly enhanced bacterial resistance against the killing effect of fish serum. Together these results indicate that fish CD59 may to some degrees facilitate a general escape of bacteria from complement-mediated immunity. (C) 2016 Elsevier Ltd. All rights reserved.
KeywordCd59 Cynoglossus Semilaevis Complement Activation Bacterial Infection
DOI10.1016/j.fsi.2016.09.051
Indexed BySCI
Language英语
WOS IDWOS:000387523100053
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136205
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Sui, Zhi-hai,Li, Mo-fei,Sun, Li. Tongue sole (Cynoglossus semilaevis) CD59: A complement inhibitor that binds bacterial cells and promotes bacterial escape from the killing of fish serum[J]. FISH & SHELLFISH IMMUNOLOGY,2016,58:442-448.
APA Sui, Zhi-hai,Li, Mo-fei,&Sun, Li.(2016).Tongue sole (Cynoglossus semilaevis) CD59: A complement inhibitor that binds bacterial cells and promotes bacterial escape from the killing of fish serum.FISH & SHELLFISH IMMUNOLOGY,58,442-448.
MLA Sui, Zhi-hai,et al."Tongue sole (Cynoglossus semilaevis) CD59: A complement inhibitor that binds bacterial cells and promotes bacterial escape from the killing of fish serum".FISH & SHELLFISH IMMUNOLOGY 58(2016):442-448.
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