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Tongue sole (Cynoglossus semilaevis) CD59: A complement inhibitor that binds bacterial cells and promotes bacterial escape from the killing of fish serum
Sui, Zhi-hai1,2,3; Li, Mo-fei1,2; Sun, Li1,2
2016-11-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号58页码:442-448
文章类型Article
摘要CD59 is a complement regulatory protein that inhibits the formation of membrane attack complex of complement. In this study, we examined the expression and activity of tongue sole (Cynoglossus semilaevis) CD59 (CsCD59). CsCD59 possesses the conserved structural features of CD59 and shares 33%-46% sequence identities with other fish CD59. Expression of CsCD59 was high in liver, spleen, and muscle, and was stimulated by infection of bacterial pathogens. Recombinant CsCD59 (rCsCD59) exhibited an apparent inhibition effect on the activation of tongue sole serum complement. ELISA and microscopy detected binding of rCsCD59 to a number of Gram-negative and Gram-positive bacteria. Interaction with rCsCD59 did not affect bacterial viability but significantly enhanced bacterial resistance against the killing effect of fish serum. Together these results indicate that fish CD59 may to some degrees facilitate a general escape of bacteria from complement-mediated immunity. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Cd59 Cynoglossus Semilaevis Complement Activation Bacterial Infection
DOI10.1016/j.fsi.2016.09.051
收录类别SCI
语种英语
WOS记录号WOS:000387523100053
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136205
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
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Sui, Zhi-hai,Li, Mo-fei,Sun, Li. Tongue sole (Cynoglossus semilaevis) CD59: A complement inhibitor that binds bacterial cells and promotes bacterial escape from the killing of fish serum[J]. FISH & SHELLFISH IMMUNOLOGY,2016,58:442-448.
APA Sui, Zhi-hai,Li, Mo-fei,&Sun, Li.(2016).Tongue sole (Cynoglossus semilaevis) CD59: A complement inhibitor that binds bacterial cells and promotes bacterial escape from the killing of fish serum.FISH & SHELLFISH IMMUNOLOGY,58,442-448.
MLA Sui, Zhi-hai,et al."Tongue sole (Cynoglossus semilaevis) CD59: A complement inhibitor that binds bacterial cells and promotes bacterial escape from the killing of fish serum".FISH & SHELLFISH IMMUNOLOGY 58(2016):442-448.
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