IOCAS-IR  > 实验海洋生物学重点实验室
CD94 of tongue sole Cynoglossus semilaevis binds a wide arrange of bacteria and possesses antibacterial activity
Li, Xue-peng1,2,3; Hu, Yong-hua1,2
2016-11-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号58页码:641-649
文章类型Article
摘要In this study, we examined the expression patterns and the functions of the tongue sole Cynoglossus semilaevis CD94, CsCD94. CsCD94 is composed of 209 amino acid residues and shares 43.0-50.2% overall identities with known teleost CD94 sequence. CsCD94 has a C-type lectin-like domain. Expression of CsCD94 occurred in multiple tissues and was upregulated during bacterial infection. Recombinant CsCD94 (rCsCD94) exhibited apparent binding and agglutinating activities against both Gram-positive and Gram-negative bacteria in a Ca2+-dependent manner. Treatment of bacteria with rCsCD94 enhanced phagocytosis of the bacteria by peripheral blood leukocytes. Furthermore, incubation of rCsCD94 with bacteria reduced the survival of the bacteria in vitro. Taken together, these results indicate that rCsCD94 is a key factor in the bactericidal and phagocytic effects of tongue sole, and reveal for the first time an essential role of fish CD94 in antibacterial immunity, thereby adding insight into the function of CD94. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Cd94 Cynoglossus Semilaevis Agglutination Phagocytosis Antibacterial
DOI10.1016/j.fsi.2016.10.005
收录类别SCI
语种英语
WOS记录号WOS:000387523100074
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136199
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, Xue-peng,Hu, Yong-hua. CD94 of tongue sole Cynoglossus semilaevis binds a wide arrange of bacteria and possesses antibacterial activity[J]. FISH & SHELLFISH IMMUNOLOGY,2016,58:641-649.
APA Li, Xue-peng,&Hu, Yong-hua.(2016).CD94 of tongue sole Cynoglossus semilaevis binds a wide arrange of bacteria and possesses antibacterial activity.FISH & SHELLFISH IMMUNOLOGY,58,641-649.
MLA Li, Xue-peng,et al."CD94 of tongue sole Cynoglossus semilaevis binds a wide arrange of bacteria and possesses antibacterial activity".FISH & SHELLFISH IMMUNOLOGY 58(2016):641-649.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
CD94 of tongue sole (2445KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Xue-peng]的文章
[Hu, Yong-hua]的文章
百度学术
百度学术中相似的文章
[Li, Xue-peng]的文章
[Hu, Yong-hua]的文章
必应学术
必应学术中相似的文章
[Li, Xue-peng]的文章
[Hu, Yong-hua]的文章
相关权益政策
暂无数据
收藏/分享
文件名: CD94 of tongue sole Cynoglossus semilaevis binds a wide arrange of bacteria and possesses antibacterial activity.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。