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New Chromone, Isocoumarin, and Indole Alkaloid Derivatives from three Sponge-derived Fungal Strains
Meng, Ling-Hong1; Chen, Hui-Qin2; Form, Imke2; Konuklugil, Belma3; Proksch, Peter2; Wang, Bin-Gui1
2016-09-01
Source PublicationNATURAL PRODUCT COMMUNICATIONS
Volume11Issue:9Pages:1293-1296
SubtypeArticle
AbstractTwo new chromone derivatives, 2-hydroxymethy1-3-methyl-7-methoxychromone (1) and 2-hydroxymethyl-3-tert-butyl-7-methoxychromone(2), together with a related known compound, 2,3-dimethyl-7-methoxychromone (3), were isolated from Rhinocladiella sp. (IO2), a fungus obtained from the sponge Ircinia oros. Furthermore, a new isocoumarin derivative, 3-(3-chloro-2-hydroxypropyl)-8-hydroxy-6-methoxy-isochromen-1-one (4) and a known analogue 3-KR)3,3- dichloro-2-hydroxypropy11-8-hydroxy-6-methoxy-1H-isochromen-1 -one (dichlorodiaportin, 5), were identified from sponge -derived fungal strain Clonostachys sp. (AP4.1), while a new indole alkaloid 1-(4-hydroxybenzoypindole-3-carbaldehyde (6) was obtained from the sponge -derived fungus Engyodontium album (IVB1b). The structures of these compounds were established by NMR spectroscopic and mass spectrometric data analysis, as well as by comparison with literature reports. Compounds 4 and 6 were examined for cytotoxic and antimicrobial activities, respectively. None of them showed potent activity.
KeywordSponge-derived Fungus Chromone Isocoumarin Indole Alkaloid
Indexed BySCI
Language英语
WOS IDWOS:000384513600027
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136188
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol,Key Lab Expt Marine, Naihai Rd 7, Qingdao 266071, Peoples R China
2.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany
3.Ankara Univ, Dept Pharmacognosy, Fac Pharm, TR-06110 Ankara, Turkey
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Meng, Ling-Hong,Chen, Hui-Qin,Form, Imke,et al. New Chromone, Isocoumarin, and Indole Alkaloid Derivatives from three Sponge-derived Fungal Strains[J]. NATURAL PRODUCT COMMUNICATIONS,2016,11(9):1293-1296.
APA Meng, Ling-Hong,Chen, Hui-Qin,Form, Imke,Konuklugil, Belma,Proksch, Peter,&Wang, Bin-Gui.(2016).New Chromone, Isocoumarin, and Indole Alkaloid Derivatives from three Sponge-derived Fungal Strains.NATURAL PRODUCT COMMUNICATIONS,11(9),1293-1296.
MLA Meng, Ling-Hong,et al."New Chromone, Isocoumarin, and Indole Alkaloid Derivatives from three Sponge-derived Fungal Strains".NATURAL PRODUCT COMMUNICATIONS 11.9(2016):1293-1296.
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