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| Stable and Biocompatible Colloidal Dispersions of Superparamagnetic Iron Oxide Nanoparticles with Minimum Aggregation for Biomedical Applications | |
| Wan, Jiaqi1; Yuan, Ruiting1; Zhang, Chongyu1; Wu, Ning2; Yan, Fengying1; Yu, Shoushan1; Chen, Kezheng1 | |
| 2016-10-20 | |
| 发表期刊 | JOURNAL OF PHYSICAL CHEMISTRY C
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| 卷号 | 120期号:41页码:23799-23806 |
| 文章类型 | Article |
| 摘要 | In this article, a simple and scalable method for preparing well-defined and highly stable colloidal dispersions of superparamagnetic iron oxide nanoparticles (IONPs) is reported. The IONPs with narrow size distribution were synthesized by polyol process. Nonhazardous sodium tripolyphosphate (STPP) was immobilized on the surface of IONPs via effective ligand exchange in aqueous phase. Then the STPP-capped IONPs were purified by tangential flow ultrafitration. The polyanionic nature of STPP and its strong coordination capability to iron oxide warrant the IONPs longterm colloidal stability even in phosphate-buffer saline. Because the ligand exchange and purification process did not involve repeated precipitation by organic solvents, the unwanted irreversible aggregation and organic impurities were avoided to the utmost extent. The absence of aggregation renders the IONPs well-defined magnetic behaviors and optimized relaxometric properties for T-1-weighted magnetic resonance imaging. The in vitro cytotoxicity test suggests that the STPP-capped IONPs possess little toxicity. In vivo MRI experiment carried out with a mouse model demonstrates the excellent T-1-weighted MR contrast enhancement capability of the IONPs. This new kind of IONPs is expected to be applicable in various biomedical applications. |
| DOI | 10.1021/acs.jpcc.6b06614 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000386107600055 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/136172 |
| 专题 | 海洋生态与环境科学重点实验室 |
| 作者单位 | 1.Qingdao Univ Sci & Technol, Sch Mat Sci & Engn, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Jiaqi,Yuan, Ruiting,Zhang, Chongyu,et al. Stable and Biocompatible Colloidal Dispersions of Superparamagnetic Iron Oxide Nanoparticles with Minimum Aggregation for Biomedical Applications[J]. JOURNAL OF PHYSICAL CHEMISTRY C,2016,120(41):23799-23806. |
| APA | Wan, Jiaqi.,Yuan, Ruiting.,Zhang, Chongyu.,Wu, Ning.,Yan, Fengying.,...&Chen, Kezheng.(2016).Stable and Biocompatible Colloidal Dispersions of Superparamagnetic Iron Oxide Nanoparticles with Minimum Aggregation for Biomedical Applications.JOURNAL OF PHYSICAL CHEMISTRY C,120(41),23799-23806. |
| MLA | Wan, Jiaqi,et al."Stable and Biocompatible Colloidal Dispersions of Superparamagnetic Iron Oxide Nanoparticles with Minimum Aggregation for Biomedical Applications".JOURNAL OF PHYSICAL CHEMISTRY C 120.41(2016):23799-23806. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Stable and Biocompat（5384KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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