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Stable and Biocompatible Colloidal Dispersions of Superparamagnetic Iron Oxide Nanoparticles with Minimum Aggregation for Biomedical Applications
Wan, Jiaqi1; Yuan, Ruiting1; Zhang, Chongyu1; Wu, Ning2; Yan, Fengying1; Yu, Shoushan1; Chen, Kezheng1
2016-10-20
Source PublicationJOURNAL OF PHYSICAL CHEMISTRY C
Volume120Issue:41Pages:23799-23806
SubtypeArticle
AbstractIn this article, a simple and scalable method for preparing well-defined and highly stable colloidal dispersions of superparamagnetic iron oxide nanoparticles (IONPs) is reported. The IONPs with narrow size distribution were synthesized by polyol process. Nonhazardous sodium tripolyphosphate (STPP) was immobilized on the surface of IONPs via effective ligand exchange in aqueous phase. Then the STPP-capped IONPs were purified by tangential flow ultrafitration. The polyanionic nature of STPP and its strong coordination capability to iron oxide warrant the IONPs longterm colloidal stability even in phosphate-buffer saline. Because the ligand exchange and purification process did not involve repeated precipitation by organic solvents, the unwanted irreversible aggregation and organic impurities were avoided to the utmost extent. The absence of aggregation renders the IONPs well-defined magnetic behaviors and optimized relaxometric properties for T-1-weighted magnetic resonance imaging. The in vitro cytotoxicity test suggests that the STPP-capped IONPs possess little toxicity. In vivo MRI experiment carried out with a mouse model demonstrates the excellent T-1-weighted MR contrast enhancement capability of the IONPs. This new kind of IONPs is expected to be applicable in various biomedical applications.
DOI10.1021/acs.jpcc.6b06614
Indexed BySCI
Language英语
WOS IDWOS:000386107600055
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136172
Collection海洋生态与环境科学重点实验室
Affiliation1.Qingdao Univ Sci & Technol, Sch Mat Sci & Engn, Qingdao 266042, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Wan, Jiaqi,Yuan, Ruiting,Zhang, Chongyu,et al. Stable and Biocompatible Colloidal Dispersions of Superparamagnetic Iron Oxide Nanoparticles with Minimum Aggregation for Biomedical Applications[J]. JOURNAL OF PHYSICAL CHEMISTRY C,2016,120(41):23799-23806.
APA Wan, Jiaqi.,Yuan, Ruiting.,Zhang, Chongyu.,Wu, Ning.,Yan, Fengying.,...&Chen, Kezheng.(2016).Stable and Biocompatible Colloidal Dispersions of Superparamagnetic Iron Oxide Nanoparticles with Minimum Aggregation for Biomedical Applications.JOURNAL OF PHYSICAL CHEMISTRY C,120(41),23799-23806.
MLA Wan, Jiaqi,et al."Stable and Biocompatible Colloidal Dispersions of Superparamagnetic Iron Oxide Nanoparticles with Minimum Aggregation for Biomedical Applications".JOURNAL OF PHYSICAL CHEMISTRY C 120.41(2016):23799-23806.
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