IOCAS-IR  > 实验海洋生物学重点实验室
Comparative analysis of the expression patterns of eight suppressors of cytokine signaling in tongue sole, Cynoglossus semilaevis
Hao, Lian-xu1,2,3; Sun, Li1,2
2016-08-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号55页码:595-601
文章类型Article
摘要Suppressor of cytokine signaling (SOCS) family members are inhibitors of cytokine signaling pathways and key regulators of immunological homeostasis. They have been extensively studied in mammalian models, but systematic analyses of SOCS in fish are limited. In the current study, a total of eight SOCS genes from tongue sole (Cynoglossus semilaevis) were characterized. All eight CsSOCS exhibit conserved structures of SOCS and were phylogenetically grouped together with the respective SCOS members known in mammalian and teleost species. Under normal physiological conditions, the expressions of the eight CsSOCS genes were detected at varied levels in nine major tissues, with most CsSOCS highly expressed in kidney. Following challenge with intracellular and extracellular bacterial pathogens, the majority of CsSOCS genes exhibited distinctly different expression profiles in a time-, tissue-, and pathogen-dependent manner. In general, intracellular pathogen caused wider and higher levels of CsSOCS expressions than extracellular pathogen. These results suggest that different members of SOCSs in teleost may play different roles in the infection processes of different bacterial pathogens. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Suppressor Of Cytokine Signaling Cynoglossus Semilaevis Expression Bacterial Infection Immune Defense
DOI10.1016/j.fsi.2016.06.034
收录类别SCI
语种英语
WOS记录号WOS:000381537000065
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/135883
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Hao, Lian-xu,Sun, Li. Comparative analysis of the expression patterns of eight suppressors of cytokine signaling in tongue sole, Cynoglossus semilaevis[J]. FISH & SHELLFISH IMMUNOLOGY,2016,55:595-601.
APA Hao, Lian-xu,&Sun, Li.(2016).Comparative analysis of the expression patterns of eight suppressors of cytokine signaling in tongue sole, Cynoglossus semilaevis.FISH & SHELLFISH IMMUNOLOGY,55,595-601.
MLA Hao, Lian-xu,et al."Comparative analysis of the expression patterns of eight suppressors of cytokine signaling in tongue sole, Cynoglossus semilaevis".FISH & SHELLFISH IMMUNOLOGY 55(2016):595-601.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Comparative analysis(1575KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Hao, Lian-xu]的文章
[Sun, Li]的文章
百度学术
百度学术中相似的文章
[Hao, Lian-xu]的文章
[Sun, Li]的文章
必应学术
必应学术中相似的文章
[Hao, Lian-xu]的文章
[Sun, Li]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Comparative analysis of the expression patterns of eight suppressors of cytokine signaling in tongue sole, Cynoglossus semilaevis.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。