Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives | |
Hu, Linfeng1,2; Meng, Xiangtao1; Xing, Ronge1; Liu, Song1; Chen, Xiaolin1; Qin, Yukun1; Yu, Huahua1; Li, Pengcheng1 | |
2016-09-15 | |
发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
卷号 | 26期号:18页码:4548-4551 |
文章类型 | Article |
摘要 | Three novel 6-N-substituted chitosan derivatives were designed and synthesised and characterized by FTIR and NMR. The degree of substitution was calculated by elemental analysis results. The antimicrobial activities of the target compounds were evaluated by twofold serial broth dilution method and poisoned food technique. The antifungal activities of 6-aminoethylamino-6-deoxy chitosan (3), 6-butylamino-6deoxy chitosan (4) and 6-pyridyl-6-deoxy chitosan (5) were significantly increased against Rhizoctonia cerealis, Fusarium oxysporum and Botrytis cinerea, and the inhibition rate ranged from 22.48% to 63.56% at the concentration of 0.2 mg/mL. The compound 3 had better antibacterial activities than chitosan, and the minimum inhibition concentration of which ranged between 6.25 and 25 mg/L against gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Bacillus anthracis) and gram-negative bacteria (Escherichia coli, Salmonella typhi). The antibacterial activities of 6-N-substituted chitosan tended to increase with the increase of the number of -NH2 group. (C) 2015 Elsevier Ltd. All rights reserved. |
关键词 | Chitosan 6-n-substituted Chitosan Antibacterial Activity Antifungal Activity |
DOI | 10.1016/j.bmcl.2015.08.047 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000382263800031 |
引用统计 | |
文献类型 | 期刊论文 |
版本 | 出版稿 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/135863 |
专题 | 海洋生物技术研发中心 海洋环境工程技术研究发展中心 |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Henan Inst Sci & Technol, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China |
第一作者单位 | 中国科学院海洋研究所 |
推荐引用方式 GB/T 7714 | Hu, Linfeng,Meng, Xiangtao,Xing, Ronge,et al. Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(18):4548-4551. |
APA | Hu, Linfeng.,Meng, Xiangtao.,Xing, Ronge.,Liu, Song.,Chen, Xiaolin.,...&Li, Pengcheng.(2016).Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(18),4548-4551. |
MLA | Hu, Linfeng,et al."Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.18(2016):4548-4551. |
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