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Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives
Hu, Linfeng1,2; Meng, Xiangtao1; Xing, Ronge1; Liu, Song1; Chen, Xiaolin1; Qin, Yukun1; Yu, Huahua1; Li, Pengcheng1
2016-09-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷号26期号:18页码:4548-4551
文章类型Article
摘要Three novel 6-N-substituted chitosan derivatives were designed and synthesised and characterized by FTIR and NMR. The degree of substitution was calculated by elemental analysis results. The antimicrobial activities of the target compounds were evaluated by twofold serial broth dilution method and poisoned food technique. The antifungal activities of 6-aminoethylamino-6-deoxy chitosan (3), 6-butylamino-6deoxy chitosan (4) and 6-pyridyl-6-deoxy chitosan (5) were significantly increased against Rhizoctonia cerealis, Fusarium oxysporum and Botrytis cinerea, and the inhibition rate ranged from 22.48% to 63.56% at the concentration of 0.2 mg/mL. The compound 3 had better antibacterial activities than chitosan, and the minimum inhibition concentration of which ranged between 6.25 and 25 mg/L against gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Bacillus anthracis) and gram-negative bacteria (Escherichia coli, Salmonella typhi). The antibacterial activities of 6-N-substituted chitosan tended to increase with the increase of the number of -NH2 group. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Chitosan 6-n-substituted Chitosan Antibacterial Activity Antifungal Activity
DOI10.1016/j.bmcl.2015.08.047
收录类别SCI
语种英语
WOS记录号WOS:000382263800031
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文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/135863
专题海洋生物技术研发中心
海洋环境工程技术研究发展中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Henan Inst Sci & Technol, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China
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GB/T 7714
Hu, Linfeng,Meng, Xiangtao,Xing, Ronge,et al. Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(18):4548-4551.
APA Hu, Linfeng.,Meng, Xiangtao.,Xing, Ronge.,Liu, Song.,Chen, Xiaolin.,...&Li, Pengcheng.(2016).Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(18),4548-4551.
MLA Hu, Linfeng,et al."Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.18(2016):4548-4551.
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