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| Isolation, Stereochemical Study, and Antioxidant Activity of Benzofuranone Derivatives from a Mangrove-derived Fungus Eurotium rubrum MA-150 | |
Meng, Ling-Hong1,2 ; Mandi, Attila3; Li, Xiao-Ming1; Liu, Yang1,2; Kurtan, Tibor3; Wang, Bin-Gui1
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| 2016-08-01 | |
| 发表期刊 | CHIRALITY
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| 卷号 | 28期号:8页码:581-584 |
| 文章类型 | Article |
| 摘要 | Enantiomers of a 2-benzofuran-1(3H)-one derivative [(-)-1 and (+)-1] and four known analogs (2, 3, 4, 5) were isolated and identified from the culture extract of Eurotium rubrum MA-150, a fungus obtained from the mangrove-derived rizospheric soil. Their structures were established by detailed interpretation of nuclear magnetic resonance (NMR) data and the structure of (+/-)-1 was confirmed by single-crystal X-ray diffraction analysis. The absolute configuration of the enantiomers (-)-1 and (+)-1 was determined by means of online high-performance liquid chromatography - electronic circular dichroism (HPLC-ECD) measurements and time-dependent Density Functional Theory - electronic circular dichroism (TDDFT-ECD) calculations. Compounds (+/-)-1 as well as 2 and 3 exhibited potent DPPH radical scavenging activities with IC50 values of 1.23, 2.26, and 3.99 g/mL, respectively. Chirality 28:581-584, 2016. (c) 2016 Wiley Periodicals, Inc. |
| 关键词 | Marine-derived Fungus Benzofuran-1(3h)-one Hplc-ecd Tddft Calculations Dpph Radical Scavenging Activity |
| DOI | 10.1002/chir.22613 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000380950600001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/135860 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Expt Marine Biol, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol,Inst Oceanol, Naihai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Meng, Ling-Hong,Mandi, Attila,Li, Xiao-Ming,et al. Isolation, Stereochemical Study, and Antioxidant Activity of Benzofuranone Derivatives from a Mangrove-derived Fungus Eurotium rubrum MA-150[J]. CHIRALITY,2016,28(8):581-584. |
| APA | Meng, Ling-Hong,Mandi, Attila,Li, Xiao-Ming,Liu, Yang,Kurtan, Tibor,&Wang, Bin-Gui.(2016).Isolation, Stereochemical Study, and Antioxidant Activity of Benzofuranone Derivatives from a Mangrove-derived Fungus Eurotium rubrum MA-150.CHIRALITY,28(8),581-584. |
| MLA | Meng, Ling-Hong,et al."Isolation, Stereochemical Study, and Antioxidant Activity of Benzofuranone Derivatives from a Mangrove-derived Fungus Eurotium rubrum MA-150".CHIRALITY 28.8(2016):581-584. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Isolation, Stereoche（361KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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