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Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload
Jia, Yingli1,2; Sun, Yi1,2; Weng, Lin1,2; Li, Yingjie1,2; Zhang, Quanbin3; Zhou, Hong1,2; Yang, Baoxue1,2
2016-08-22
Source PublicationSCIENTIFIC REPORTS
Volume6
SubtypeArticle
AbstractAlbuminuria is a causative and aggravating factor for progressive renal damage in chronic kidney disease (CKD). The aim of this study was to determine if low molecular weight fucoidan (LMWF) could protect renal function and tubular cells from albumin overload caused injury. Treatment with 10 mg/g bovine serum albumin caused renal dysfunction, morphological changes, and overexpression of inflammation and fibrosis associated proteins in 129S2/Sv mice. LMWF (100 mg/kg) protected against kidney injury and renal dysfunction with decreased blood creatinine by 34% and urea nitrogen by 25%, increased creatinine clearance by 48%, and decreased significantly urinary albumin concentration. In vitro proximal tubule epithelial cell (NRK-52E) model showed that LMWF dose-dependently inhibited overexpression of proinflammatory and profibrotic factors, oxidative stress and apoptosis caused by albumin overload. These experimental results indicate that LMWF protects against albumin overload caused renal injury by inhibiting inflammation, fibrosis, oxidative stress and apoptosis, which suggests that LMWF could be a promising candidate drug for preventing CKD.
DOI10.1038/srep31759
Indexed BySCI
Language英语
WOS IDWOS:000381706900002
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/135857
Collection海洋生物技术研发中心
Affiliation1.Peking Univ, Minist Educ, State Key Lab Nat & Biomimet Drugs, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Jia, Yingli,Sun, Yi,Weng, Lin,et al. Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload[J]. SCIENTIFIC REPORTS,2016,6.
APA Jia, Yingli.,Sun, Yi.,Weng, Lin.,Li, Yingjie.,Zhang, Quanbin.,...&Yang, Baoxue.(2016).Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload.SCIENTIFIC REPORTS,6.
MLA Jia, Yingli,et al."Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload".SCIENTIFIC REPORTS 6(2016).
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