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Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy
Xu, Yingjie1,2,3; Zhang, Quanbin1,2,5; Luo, Dali4; Wang, Jing1,2; Duan, Delin1,2,5
2016-10-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume91Pages:233-240
SubtypeArticle
AbstractDiabetic nephropathy (DN) is a serious microvascular complication that can lead to chronic and end stage renal failure. It is understood that inflammation is associated with the onset and process of DN. Low molecular weight fucoidan (LMWF) isolated from Saccharina japonica has anti-inflammatory properties. Therefore, this study aimed to explore the mechanism of LMWF in DN model induced by streptozotocin. The biochemical indices levels showed LMWF reduced the DN diagnostic indices to protect renal function. The HE stained sections exhibited LMWF protected normal morphological structures and reduced inflammatory cell infiltration in the kidneys of DN rats. Furthermore, the levels of P-selectin and selectin-dependent inflammatory cytokines resulting from LMWF were obviously decreased at both the transcriptional and protein levels. Thus, our results found that LMWF protected the renal function in DN rats and alleviated inflammation through the modulation of P-selectin and inflammatory cytokines. LMWF may have therapeutic potential against DN. (C) 2016 Elsevier B.V. All rights reserved.
KeywordFucoidan Diabetic Nephropathy P-selectin
DOI10.1016/j.ijbiomac.2016.05.081
Indexed BySCI
Language英语
WOS IDWOS:000382339200028
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/135847
Collection实验海洋生物学重点实验室
海洋生物技术研发中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Beijing 100069, Peoples R China
5.State Key Lab Seaweed Bioact Subst, Qingdao 266000, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
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Xu, Yingjie,Zhang, Quanbin,Luo, Dali,et al. Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2016,91:233-240.
APA Xu, Yingjie,Zhang, Quanbin,Luo, Dali,Wang, Jing,&Duan, Delin.(2016).Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,91,233-240.
MLA Xu, Yingjie,et al."Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 91(2016):233-240.
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