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Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy
Xu, Yingjie1,2,3; Zhang, Quanbin1,2,5; Luo, Dali4; Wang, Jing1,2; Duan, Delin1,2,5
2016-10-01
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号91页码:233-240
文章类型Article
摘要Diabetic nephropathy (DN) is a serious microvascular complication that can lead to chronic and end stage renal failure. It is understood that inflammation is associated with the onset and process of DN. Low molecular weight fucoidan (LMWF) isolated from Saccharina japonica has anti-inflammatory properties. Therefore, this study aimed to explore the mechanism of LMWF in DN model induced by streptozotocin. The biochemical indices levels showed LMWF reduced the DN diagnostic indices to protect renal function. The HE stained sections exhibited LMWF protected normal morphological structures and reduced inflammatory cell infiltration in the kidneys of DN rats. Furthermore, the levels of P-selectin and selectin-dependent inflammatory cytokines resulting from LMWF were obviously decreased at both the transcriptional and protein levels. Thus, our results found that LMWF protected the renal function in DN rats and alleviated inflammation through the modulation of P-selectin and inflammatory cytokines. LMWF may have therapeutic potential against DN. (C) 2016 Elsevier B.V. All rights reserved.
关键词Fucoidan Diabetic Nephropathy P-selectin
DOI10.1016/j.ijbiomac.2016.05.081
收录类别SCI
语种英语
WOS记录号WOS:000382339200028
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/135847
专题实验海洋生物学重点实验室
海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Beijing 100069, Peoples R China
5.State Key Lab Seaweed Bioact Subst, Qingdao 266000, Peoples R China
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Xu, Yingjie,Zhang, Quanbin,Luo, Dali,et al. Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2016,91:233-240.
APA Xu, Yingjie,Zhang, Quanbin,Luo, Dali,Wang, Jing,&Duan, Delin.(2016).Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,91,233-240.
MLA Xu, Yingjie,et al."Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 91(2016):233-240.
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