IOCAS-IR  > 实验海洋生物学重点实验室
CsPTX1, a pentraxin of Cynoglossus semilaevis, is an innate immunity factor with antibacterial effects
Wang, Ting1,2,3; Zhang, Jian1,2
2016-09-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号56页码:12-20
文章类型Article
摘要Pentraxin 1 (PTX1) is a member of the pentraxin protein family, which plays important roles in the innate immunity of vertebrates. In fish, the biological function of PTX1 is essentially unknown. In this study, we examined the expression and function of a PTX homologue (CsPTX1) from the tongue sole, Cynoglossus semilaevis. CsPTX1 contains 223 amino acids and shares 49.3%-38.8% overall sequence identity with other known fish pentraxins. CsPTX1 is expressed in multiple tissues and is upregulated by bacterial and viral infection. CsPTX1 contains a pentraxin domain, which is known to bind extracellular antigens, and recombinant CsPTX1 (rCsPTX1) bound a wide range of Gram-positive and Gram-negative bacteria. rCsPTX1 also agglutinated all the bacteria tested in a Ca2+-dependent manner and the agglutinating capacity of rCsPTX1 was abolished in the absence of calcium. As well as its ability to agglutinate bacterial cells, rCsPTX1 displayed apparent bacteriostatic activity against Pseudomonas fluorescens in vitro by influencing the permeability of the microbial envelope. When introduced in vivo, rCsPTX1 enhanced the host's resistance to bacterial infection. These results indicate that CsPTX1 is a classic pattern recognition molecule that defends C semilaevis against bacterial infection. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Pentraxin Cynoglossus Semilaevis Innate Immunity Bacterial Agglutination Antibacterial Effect
DOI10.1016/j.fsi.2016.06.055
收录类别SCI
语种英语
WOS记录号WOS:000383292200002
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/135839
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Ting,Zhang, Jian. CsPTX1, a pentraxin of Cynoglossus semilaevis, is an innate immunity factor with antibacterial effects[J]. FISH & SHELLFISH IMMUNOLOGY,2016,56:12-20.
APA Wang, Ting,&Zhang, Jian.(2016).CsPTX1, a pentraxin of Cynoglossus semilaevis, is an innate immunity factor with antibacterial effects.FISH & SHELLFISH IMMUNOLOGY,56,12-20.
MLA Wang, Ting,et al."CsPTX1, a pentraxin of Cynoglossus semilaevis, is an innate immunity factor with antibacterial effects".FISH & SHELLFISH IMMUNOLOGY 56(2016):12-20.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
CsPTX1, a pentraxin (3050KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Ting]的文章
[Zhang, Jian]的文章
百度学术
百度学术中相似的文章
[Wang, Ting]的文章
[Zhang, Jian]的文章
必应学术
必应学术中相似的文章
[Wang, Ting]的文章
[Zhang, Jian]的文章
相关权益政策
暂无数据
收藏/分享
文件名: CsPTX1, a pentraxin of Cynoglossus semilaevis, is an innate immunity factor with antibacterial effects.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。