Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189

doi:10.1021/acs.jnatprod.6b00403

IOCAS-IR > 实验海洋生物学重点实验室

	Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189
	Gao, Shu-Shan 1,2; Li, Xiao-Ming 1; Williams, Katherine 2; Proksch, Peter 3; Ji, Nai-Yun 4; Wang, Bin-Gui1
	2016-08-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
卷号	79 期号:8 页码:2066-2074
文章类型	Article
摘要	Genome mining of the fungus Mucor irregularis (formerly known as Rhizomucor variabilis) revealed the presence of various gene clusters for secondary metabolite biosynthesis, including several terpene-based clusters. Investigation into the chemical diversity of M. irregularis QEN-189, an endophytic fungus isolated from the fresh inner tissue of the marine mangrove plant Rhizophora stylosa, resulted in the discovery of 20 structurally diverse indole-diterpenes including six new compounds, namely, rhizovarins A-F (1-6). Among them, compounds 1-3 represent the most complex members of the reported indole-diterpenes. The presence of an unusual acetal linked to a hemiketal (1) or a ketal (2 and 3) in an unprecedented 4,6,6,8,5,6,6,6,6-fused indole-diterpene ring system makes them chemically unique. Their structures and absolute configurations were elucidated by spectroscopic analysis, modified Mosher's method, and chemical calculations. Each of the isolated compounds was evaluated for antitumor activity against HL-60 and A-549 cell lines.
DOI	10.1021/acs.jnatprod.6b00403
收录类别	SCI
语种	英语
WOS记录号	WOS:000382274700019
引用统计	被引频次：68[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/135754
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England 3.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Gao, Shu-Shan,Li, Xiao-Ming,Williams, Katherine,et al. Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(8):2066-2074.
APA	Gao, Shu-Shan,Li, Xiao-Ming,Williams, Katherine,Proksch, Peter,Ji, Nai-Yun,&Wang, Bin-Gui.(2016).Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189.JOURNAL OF NATURAL PRODUCTS,79(8),2066-2074.
MLA	Gao, Shu-Shan,et al."Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189".JOURNAL OF NATURAL PRODUCTS 79.8(2016):2066-2074.

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