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Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189
Gao, Shu-Shan1,2; Li, Xiao-Ming1; Williams, Katherine2; Proksch, Peter3; Ji, Nai-Yun4; Wang, Bin-Gui1
2016-08-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume79Issue:8Pages:2066-2074
SubtypeArticle
AbstractGenome mining of the fungus Mucor irregularis (formerly known as Rhizomucor variabilis) revealed the presence of various gene clusters for secondary metabolite biosynthesis, including several terpene-based clusters. Investigation into the chemical diversity of M. irregularis QEN-189, an endophytic fungus isolated from the fresh inner tissue of the marine mangrove plant Rhizophora stylosa, resulted in the discovery of 20 structurally diverse indole-diterpenes including six new compounds, namely, rhizovarins A-F (1-6). Among them, compounds 1-3 represent the most complex members of the reported indole-diterpenes. The presence of an unusual acetal linked to a hemiketal (1) or a ketal (2 and 3) in an unprecedented 4,6,6,8,5,6,6,6,6-fused indole-diterpene ring system makes them chemically unique. Their structures and absolute configurations were elucidated by spectroscopic analysis, modified Mosher's method, and chemical calculations. Each of the isolated compounds was evaluated for antitumor activity against HL-60 and A-549 cell lines.
DOI10.1021/acs.jnatprod.6b00403
Indexed BySCI
Language英语
WOS IDWOS:000382274700019
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/135754
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
3.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Gao, Shu-Shan,Li, Xiao-Ming,Williams, Katherine,et al. Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(8):2066-2074.
APA Gao, Shu-Shan,Li, Xiao-Ming,Williams, Katherine,Proksch, Peter,Ji, Nai-Yun,&Wang, Bin-Gui.(2016).Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189.JOURNAL OF NATURAL PRODUCTS,79(8),2066-2074.
MLA Gao, Shu-Shan,et al."Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189".JOURNAL OF NATURAL PRODUCTS 79.8(2016):2066-2074.
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