IOCAS-IR  > 实验海洋生物学重点实验室
Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189
Gao, Shu-Shan1,2; Li, Xiao-Ming1; Williams, Katherine2; Proksch, Peter3; Ji, Nai-Yun4; Wang, Bin-Gui1
2016-08-01
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号79期号:8页码:2066-2074
文章类型Article
摘要Genome mining of the fungus Mucor irregularis (formerly known as Rhizomucor variabilis) revealed the presence of various gene clusters for secondary metabolite biosynthesis, including several terpene-based clusters. Investigation into the chemical diversity of M. irregularis QEN-189, an endophytic fungus isolated from the fresh inner tissue of the marine mangrove plant Rhizophora stylosa, resulted in the discovery of 20 structurally diverse indole-diterpenes including six new compounds, namely, rhizovarins A-F (1-6). Among them, compounds 1-3 represent the most complex members of the reported indole-diterpenes. The presence of an unusual acetal linked to a hemiketal (1) or a ketal (2 and 3) in an unprecedented 4,6,6,8,5,6,6,6,6-fused indole-diterpene ring system makes them chemically unique. Their structures and absolute configurations were elucidated by spectroscopic analysis, modified Mosher's method, and chemical calculations. Each of the isolated compounds was evaluated for antitumor activity against HL-60 and A-549 cell lines.
DOI10.1021/acs.jnatprod.6b00403
收录类别SCI
语种英语
WOS记录号WOS:000382274700019
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/135754
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
3.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714
Gao, Shu-Shan,Li, Xiao-Ming,Williams, Katherine,et al. Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(8):2066-2074.
APA Gao, Shu-Shan,Li, Xiao-Ming,Williams, Katherine,Proksch, Peter,Ji, Nai-Yun,&Wang, Bin-Gui.(2016).Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189.JOURNAL OF NATURAL PRODUCTS,79(8),2066-2074.
MLA Gao, Shu-Shan,et al."Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189".JOURNAL OF NATURAL PRODUCTS 79.8(2016):2066-2074.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Rhizovarins A-F, Ind(1780KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Gao, Shu-Shan]的文章
[Li, Xiao-Ming]的文章
[Williams, Katherine]的文章
百度学术
百度学术中相似的文章
[Gao, Shu-Shan]的文章
[Li, Xiao-Ming]的文章
[Williams, Katherine]的文章
必应学术
必应学术中相似的文章
[Gao, Shu-Shan]的文章
[Li, Xiao-Ming]的文章
[Williams, Katherine]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。