| The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity | |
Jin, Weihua1,3; Zhang, Wenjing1,2 ; Liang, Hongze4; Zhang, Quanbin1,3
| |
| 2016 | |
| 发表期刊 | MARINE DRUGS
 |
| 卷号 | 14期号:1 |
| 文章类型 | Article |
| 摘要 | In this study, 33 different polysaccharides were prepared to investigate the structure-activity relationships between the polysaccharides, mainly from marine algae, and anti-complement activity in the classical pathway. Factors considered included extraction methods, fractionations, molecular weight, molar ratio of galactose to fucose, sulfate, uronic acid (UA) content, linkage, branching, and the type of monosaccharide. It was shown that the larger the molecular weights, the better the activities. The molar ratio of galactose (Gal) to fucose (Fuc) was a positive factor at a concentration lower than 10 mu g/mL, while it had no effect at a concentration more than 10 mu g/mL. In addition, sulfate was necessary; however, the sulfate content, the sulfate pattern, linkage and branching had no effect at a concentration of more than 10 mu g/mL. Moreover, the type of monosaccharide had no effect. Laminaran and UA fractions had no activity; however, they could reduce the activity by decreasing the effective concentration of the active composition when they were mixed with the active compositions. The effect of the extraction methods could not be determined. Finally, it was observed that sulfated galactofucan showed good anti-complement activity after separation. |
| 关键词 | Marine Algae Polysaccharides Anti-complement Activity Structure-activity Relationship |
| DOI | 10.3390/md14010003 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000374586800003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/131088 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 4.Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Jin, Weihua,Zhang, Wenjing,Liang, Hongze,et al. The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity[J]. MARINE DRUGS,2016,14(1). |
| APA | Jin, Weihua,Zhang, Wenjing,Liang, Hongze,&Zhang, Quanbin.(2016).The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity.MARINE DRUGS,14(1). |
| MLA | Jin, Weihua,et al."The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity".MARINE DRUGS 14.1(2016). |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Distribution of thal（2813KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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