IOCAS-IR  > 海洋生物技术研发中心
The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity
Jin, Weihua1,3; Zhang, Wenjing1,2; Liang, Hongze4; Zhang, Quanbin1,3
2016
发表期刊MARINE DRUGS
卷号14期号:1
文章类型Article
摘要In this study, 33 different polysaccharides were prepared to investigate the structure-activity relationships between the polysaccharides, mainly from marine algae, and anti-complement activity in the classical pathway. Factors considered included extraction methods, fractionations, molecular weight, molar ratio of galactose to fucose, sulfate, uronic acid (UA) content, linkage, branching, and the type of monosaccharide. It was shown that the larger the molecular weights, the better the activities. The molar ratio of galactose (Gal) to fucose (Fuc) was a positive factor at a concentration lower than 10 mu g/mL, while it had no effect at a concentration more than 10 mu g/mL. In addition, sulfate was necessary; however, the sulfate content, the sulfate pattern, linkage and branching had no effect at a concentration of more than 10 mu g/mL. Moreover, the type of monosaccharide had no effect. Laminaran and UA fractions had no activity; however, they could reduce the activity by decreasing the effective concentration of the active composition when they were mixed with the active compositions. The effect of the extraction methods could not be determined. Finally, it was observed that sulfated galactofucan showed good anti-complement activity after separation.
关键词Marine Algae Polysaccharides Anti-complement Activity Structure-activity Relationship
DOI10.3390/md14010003
收录类别SCI
语种英语
WOS记录号WOS:000374586800003
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/131088
专题海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
4.Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714
Jin, Weihua,Zhang, Wenjing,Liang, Hongze,et al. The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity[J]. MARINE DRUGS,2016,14(1).
APA Jin, Weihua,Zhang, Wenjing,Liang, Hongze,&Zhang, Quanbin.(2016).The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity.MARINE DRUGS,14(1).
MLA Jin, Weihua,et al."The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity".MARINE DRUGS 14.1(2016).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Distribution of thal(2813KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jin, Weihua]的文章
[Zhang, Wenjing]的文章
[Liang, Hongze]的文章
百度学术
百度学术中相似的文章
[Jin, Weihua]的文章
[Zhang, Wenjing]的文章
[Liang, Hongze]的文章
必应学术
必应学术中相似的文章
[Jin, Weihua]的文章
[Zhang, Wenjing]的文章
[Liang, Hongze]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Distribution of thallium in the Bohai Sea_ implications for hydrodynamic forces and anthropogenic impact.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。