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The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity
Jin, Weihua1,3; Zhang, Wenjing1,2; Liang, Hongze4; Zhang, Quanbin1,3
2016
Source PublicationMARINE DRUGS
Volume14Issue:1
SubtypeArticle
AbstractIn this study, 33 different polysaccharides were prepared to investigate the structure-activity relationships between the polysaccharides, mainly from marine algae, and anti-complement activity in the classical pathway. Factors considered included extraction methods, fractionations, molecular weight, molar ratio of galactose to fucose, sulfate, uronic acid (UA) content, linkage, branching, and the type of monosaccharide. It was shown that the larger the molecular weights, the better the activities. The molar ratio of galactose (Gal) to fucose (Fuc) was a positive factor at a concentration lower than 10 mu g/mL, while it had no effect at a concentration more than 10 mu g/mL. In addition, sulfate was necessary; however, the sulfate content, the sulfate pattern, linkage and branching had no effect at a concentration of more than 10 mu g/mL. Moreover, the type of monosaccharide had no effect. Laminaran and UA fractions had no activity; however, they could reduce the activity by decreasing the effective concentration of the active composition when they were mixed with the active compositions. The effect of the extraction methods could not be determined. Finally, it was observed that sulfated galactofucan showed good anti-complement activity after separation.
KeywordMarine Algae Polysaccharides Anti-complement Activity Structure-activity Relationship
DOI10.3390/md14010003
Indexed BySCI
Language英语
WOS IDWOS:000374586800003
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/131088
Collection海洋生物技术研发中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
4.Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Jin, Weihua,Zhang, Wenjing,Liang, Hongze,et al. The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity[J]. MARINE DRUGS,2016,14(1).
APA Jin, Weihua,Zhang, Wenjing,Liang, Hongze,&Zhang, Quanbin.(2016).The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity.MARINE DRUGS,14(1).
MLA Jin, Weihua,et al."The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity".MARINE DRUGS 14.1(2016).
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