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A High-Density SNP Genetic Linkage Map and QTL Analysis of Growth-Related Traits in a Hybrid Family of Oysters (Crassostrea gigas x Crassostrea angulata) Using Genotyping-by-Sequencing
Wang, Jinpeng1,2,3,5; Li, Li1,4,5; Zhang, Guofan1,3,5
2016-05-01
发表期刊G3-GENES GENOMES GENETICS
卷号6期号:5页码:1417-1426
文章类型Article
摘要Oysters are among the most important species in global aquaculture. Crassostrea gigas, and its subspecies C. angulata, are the major cultured species. To determine the genetic basis of growth-related traits in oysters, we constructed a second-generation linkage map from 3367 single-nucleotide polymorphisms (SNPs) based on genotyping-by-sequencing, genotyped from a C. gigas x C. angulata hybrid family. These 3367 SNPs were distributed on 1695 markers, which were assigned to 10 linkage groups. The genetic linkage map had a total length of 1084.3 cM, with an average of 0.8 cM between markers; it thus represents the densest genetic map constructed for oysters to date. Twenty-seven quantitative trait loci (QTL) for five growth-related traits were detected. These QTL could explain 4.2-7.7% (mean = 5.4%) of the phenotypic variation. In total, 50.8% of phenotypic variance for shell width, 7.7% for mass weight, and 34.1% for soft tissue weight were explained. The detected QTL were distributed among eight linkage groups, and more than half (16) were concentrated within narrow regions in their respective linkage groups. Thirty-eight annotated genes were identified within the QTL regions, two of which are key genes for carbohydrate metabolism. Other genes were found to participate in assembly and regulation of the actin cytoskeleton, signal transduction, and regulation of cell differentiation and development. The newly developed high-density genetic map, and the QTL and candidate genes identified provide a valuable genetic resource and a basis for marker-assisted selection for C. gigas and C. angulata.
关键词Single Nucleotide Polymorphisms Reduced-representation Sequencing Distortion Of Segregation Ratios Missing Data Imputation Growth-related Traits Candidate Genes
DOI10.1534/g3.116.026971
收录类别SCI
语种英语
WOS记录号WOS:000376294400025
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/131075
专题海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Lab Marine Biol & Biotechnol, Qingdao 266071, Shandong, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries & Aquaculture, Qingdao 266071, Shandong, Peoples R China
5.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Shandong, Peoples R China
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Wang, Jinpeng,Li, Li,Zhang, Guofan. A High-Density SNP Genetic Linkage Map and QTL Analysis of Growth-Related Traits in a Hybrid Family of Oysters (Crassostrea gigas x Crassostrea angulata) Using Genotyping-by-Sequencing[J]. G3-GENES GENOMES GENETICS,2016,6(5):1417-1426.
APA Wang, Jinpeng,Li, Li,&Zhang, Guofan.(2016).A High-Density SNP Genetic Linkage Map and QTL Analysis of Growth-Related Traits in a Hybrid Family of Oysters (Crassostrea gigas x Crassostrea angulata) Using Genotyping-by-Sequencing.G3-GENES GENOMES GENETICS,6(5),1417-1426.
MLA Wang, Jinpeng,et al."A High-Density SNP Genetic Linkage Map and QTL Analysis of Growth-Related Traits in a Hybrid Family of Oysters (Crassostrea gigas x Crassostrea angulata) Using Genotyping-by-Sequencing".G3-GENES GENOMES GENETICS 6.5(2016):1417-1426.
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