IOCAS-IR  > 实验海洋生物学重点实验室
The simple neuroendocrine-immune regulatory network in oyster Crassostrea gigas mediates complex functions
Liu, Zhaoqun1,2; Wang, Lingling1,3; Zhou, Zhi1; Sun, Ying1,2; Wang, Mengqiang1; Wang, Hao1; Hou, Zhanhui1; Gao, Dahai1; Gao, Qiang1; Song, Linsheng3
2016-05-19
Source PublicationSCIENTIFIC REPORTS
Volume6
SubtypeArticle
AbstractThe neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of the host. In the present study, the bioinformatical analysis of the transcriptomic data from oyster Crassostrea gigas and further biological validation revealed that oyster TNF (CgTNF-1 CGI_10018786) could activate the transcription factors NF-kappa B and HSF (heat shock transcription factor) through MAPK signaling pathway, and then regulate apoptosis, redox reaction, neuro-regulation and protein folding in oyster haemocytes. The activated immune cells then released neurotransmitters including acetylcholine, norepinephrine and [Met(5)]-enkephalin to regulate the immune response by arising the expression of three TNF (CGI_10005109, CGI_10005110 and CGI_10006440) and translocating two NF-kappa B (Cgp65, CGI_10018142 and CgRel, CGI_10021567) between the cytoplasm and nuclei of haemocytes. Neurotransmitters exhibited the immunomodulation effects by influencing apoptosis and phagocytosis of oyster haemocytes. Acetylcholine and norepinephrine could down-regulate the immune response, while [Met(5)]-enkephalin up-regulate the immune response. These results suggested that the simple neuroendocrine-immune regulatory network in oyster might be activated by oyster TNF and then regulate the immune response by virtue of neurotransmitters, cytokines and transcription factors.
DOI10.1038/srep26396
Indexed BySCI
Language英语
WOS IDWOS:000376077300001
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/131074
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Ocean Univ, Minist Agr, Key Lab Mariculture & Stock Enhancement North Chi, Dalian 116023, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Liu, Zhaoqun,Wang, Lingling,Zhou, Zhi,et al. The simple neuroendocrine-immune regulatory network in oyster Crassostrea gigas mediates complex functions[J]. SCIENTIFIC REPORTS,2016,6.
APA Liu, Zhaoqun.,Wang, Lingling.,Zhou, Zhi.,Sun, Ying.,Wang, Mengqiang.,...&Song, Linsheng.(2016).The simple neuroendocrine-immune regulatory network in oyster Crassostrea gigas mediates complex functions.SCIENTIFIC REPORTS,6.
MLA Liu, Zhaoqun,et al."The simple neuroendocrine-immune regulatory network in oyster Crassostrea gigas mediates complex functions".SCIENTIFIC REPORTS 6(2016).
Files in This Item:
File Name/Size DocType Version Access License
The simple neuroendo(1574KB)期刊论文出版稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu, Zhaoqun]'s Articles
[Wang, Lingling]'s Articles
[Zhou, Zhi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu, Zhaoqun]'s Articles
[Wang, Lingling]'s Articles
[Zhou, Zhi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu, Zhaoqun]'s Articles
[Wang, Lingling]'s Articles
[Zhou, Zhi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: The simple neuroendocrine-immune regulatory network in oyster Crassostrea gigas mediates complex functions.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.