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The simple neuroendocrine-immune regulatory network in oyster Crassostrea gigas mediates complex functions
Liu, Zhaoqun1,2; Wang, Lingling1,3; Zhou, Zhi1; Sun, Ying1,2; Wang, Mengqiang1; Wang, Hao1; Hou, Zhanhui1; Gao, Dahai1; Gao, Qiang1; Song, Linsheng3
2016-05-19
发表期刊SCIENTIFIC REPORTS
卷号6
文章类型Article
摘要The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of the host. In the present study, the bioinformatical analysis of the transcriptomic data from oyster Crassostrea gigas and further biological validation revealed that oyster TNF (CgTNF-1 CGI_10018786) could activate the transcription factors NF-kappa B and HSF (heat shock transcription factor) through MAPK signaling pathway, and then regulate apoptosis, redox reaction, neuro-regulation and protein folding in oyster haemocytes. The activated immune cells then released neurotransmitters including acetylcholine, norepinephrine and [Met(5)]-enkephalin to regulate the immune response by arising the expression of three TNF (CGI_10005109, CGI_10005110 and CGI_10006440) and translocating two NF-kappa B (Cgp65, CGI_10018142 and CgRel, CGI_10021567) between the cytoplasm and nuclei of haemocytes. Neurotransmitters exhibited the immunomodulation effects by influencing apoptosis and phagocytosis of oyster haemocytes. Acetylcholine and norepinephrine could down-regulate the immune response, while [Met(5)]-enkephalin up-regulate the immune response. These results suggested that the simple neuroendocrine-immune regulatory network in oyster might be activated by oyster TNF and then regulate the immune response by virtue of neurotransmitters, cytokines and transcription factors.
DOI10.1038/srep26396
收录类别SCI
语种英语
WOS记录号WOS:000376077300001
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/131074
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Ocean Univ, Minist Agr, Key Lab Mariculture & Stock Enhancement North Chi, Dalian 116023, Peoples R China
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GB/T 7714
Liu, Zhaoqun,Wang, Lingling,Zhou, Zhi,et al. The simple neuroendocrine-immune regulatory network in oyster Crassostrea gigas mediates complex functions[J]. SCIENTIFIC REPORTS,2016,6.
APA Liu, Zhaoqun.,Wang, Lingling.,Zhou, Zhi.,Sun, Ying.,Wang, Mengqiang.,...&Song, Linsheng.(2016).The simple neuroendocrine-immune regulatory network in oyster Crassostrea gigas mediates complex functions.SCIENTIFIC REPORTS,6.
MLA Liu, Zhaoqun,et al."The simple neuroendocrine-immune regulatory network in oyster Crassostrea gigas mediates complex functions".SCIENTIFIC REPORTS 6(2016).
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