Independent Evolution of Six Families of Halogenating Enzymes

doi:10.1371/journal.pone.0154619

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	Independent Evolution of Six Families of Halogenating Enzymes
	Xu, Gangming; Wang, Bin-Gui
	2016-05-06
发表期刊	PLOS ONE
卷号	11 期号:5
文章类型	Article
摘要	Halogenated natural products are widespread in the environment, and the halogen atoms are typically vital to their bioactivities. Thus far, six families of halogenating enzymes have been identified: cofactor-free haloperoxidases (HPO), vanadium-dependent haloperoxidases (V-HPO), heme iron-dependent haloperoxidases (HI-HPO), non-heme iron-dependent halogenases (NI-HG), flavin-dependent halogenases (F-HG), and S-adenosyl-L-methionine (SAM)-dependent halogenases (S-HG). However, these halogenating enzymes with similar biological functions but distinct structures might have evolved independently. Phylogenetic and structural analyses suggest that the HPO, V-HPO, HI-HPO, NI-HG, FHG, and S-HG enzyme families may have evolutionary relationships to the alpha/beta hydrolases, acid phosphatases, peroxidases, chemotaxis phosphatases, oxidoreductases, and SAM hydroxide adenosyltransferases, respectively. These halogenating enzymes have established sequence homology, structural conservation, and mechanistic features within each family. Understanding the distinct evolutionary history of these halogenating enzymes will provide further insights into the study of their catalytic mechanisms and halogenation specificity.
DOI	10.1371/journal.pone.0154619
收录类别	SCI
语种	英语
WOS记录号	WOS:000375677000028
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/131067
专题	实验海洋生物学重点实验室
作者单位	Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Xu, Gangming,Wang, Bin-Gui. Independent Evolution of Six Families of Halogenating Enzymes[J]. PLOS ONE,2016,11(5).
APA	Xu, Gangming,&Wang, Bin-Gui.(2016).Independent Evolution of Six Families of Halogenating Enzymes.PLOS ONE,11(5).
MLA	Xu, Gangming,et al."Independent Evolution of Six Families of Halogenating Enzymes".PLOS ONE 11.5(2016).

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Independent Evolutio（1359KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览