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Independent Evolution of Six Families of Halogenating Enzymes
Xu, Gangming; Wang, Bin-Gui
2016-05-06
发表期刊PLOS ONE
卷号11期号:5
文章类型Article
摘要Halogenated natural products are widespread in the environment, and the halogen atoms are typically vital to their bioactivities. Thus far, six families of halogenating enzymes have been identified: cofactor-free haloperoxidases (HPO), vanadium-dependent haloperoxidases (V-HPO), heme iron-dependent haloperoxidases (HI-HPO), non-heme iron-dependent halogenases (NI-HG), flavin-dependent halogenases (F-HG), and S-adenosyl-L-methionine (SAM)-dependent halogenases (S-HG). However, these halogenating enzymes with similar biological functions but distinct structures might have evolved independently. Phylogenetic and structural analyses suggest that the HPO, V-HPO, HI-HPO, NI-HG, FHG, and S-HG enzyme families may have evolutionary relationships to the alpha/beta hydrolases, acid phosphatases, peroxidases, chemotaxis phosphatases, oxidoreductases, and SAM hydroxide adenosyltransferases, respectively. These halogenating enzymes have established sequence homology, structural conservation, and mechanistic features within each family. Understanding the distinct evolutionary history of these halogenating enzymes will provide further insights into the study of their catalytic mechanisms and halogenation specificity.
DOI10.1371/journal.pone.0154619
收录类别SCI
语种英语
WOS记录号WOS:000375677000028
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文献类型期刊论文
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条目标识符http://ir.qdio.ac.cn/handle/337002/131067
专题实验海洋生物学重点实验室
作者单位Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
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Xu, Gangming,Wang, Bin-Gui. Independent Evolution of Six Families of Halogenating Enzymes[J]. PLOS ONE,2016,11(5).
APA Xu, Gangming,&Wang, Bin-Gui.(2016).Independent Evolution of Six Families of Halogenating Enzymes.PLOS ONE,11(5).
MLA Xu, Gangming,et al."Independent Evolution of Six Families of Halogenating Enzymes".PLOS ONE 11.5(2016).
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