IOCAS-IR  > 实验海洋生物学重点实验室
miR-125/Pokemon auto-circuit contributes to the progression of hepatocellular carcinoma
Kong, Jing1; Liu, Xiaoping1; Li, Xiangqian1; Wu, Jinsheng2; Wu, Ning3; Chen, Jun1; Fang, Fang1
2016
Source PublicationTUMOR BIOLOGY
Volume37Issue:1Pages:511-519
SubtypeArticle
AbstractHepatocellular carcinoma (HCC) is a type of human malignant tumor occurring in hepatic tissues with high mortality. Patients benefit little from current therapeutic modalities, at least partially due to the lack of complete elucidation of molecular network regulating HCC. miR-125 and Pokemon are well-recognized tumor suppressor and oncogenes for HCC, respectively. However, the underlying mechanism by which the two genes exert their functions and the relationship between miR-125 and Pokemon is still unexplored yet. In this study, we found that there is an inverse association between miR-125 and Pokemon expression levels in HCC specimen and cell lines. Online database mining indicated that there are three putative mRNA recognition elements (MREs) of miR-125 within 3' untranslated region (3'UTR) of Pokemon. MREs of miR-125 confer the expression of luciferase with a miR-125-dependent fashion. The alteration in miR-125 abundance regulates the expression of Pokemon at both protein and mRNA levels. Overexpression of Pokemon is able to abrogate the inhibitory effect of miR-125 on HCC progression. Further study showed that Pokemon inhibits the expression of miR-125 by binding of recognition sites within its promoter. In conclusion, we found that there is an auto-regulatory circuit consisting of miR-125 and Pokemon, which promotes the progression of HCC and may be a promising therapeutic target in clinical HCC treatment.
KeywordMir-125 Pokemon Hcc
DOI10.1007/s13277-015-3596-7
Indexed BySCI
Language英语
WOS IDWOS:000374576200055
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/131045
Collection实验海洋生物学重点实验室
Affiliation1.Huaiyin Inst Technol, Fac Life Sci & Chem Engn, 1 Meicheng Rd East, Huaian 223003, Jiangsu, Peoples R China
2.Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Hepatopancreatobiliary Surg, 6 Beijing Rd West, Huaian 223300, Jiangsu, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Kong, Jing,Liu, Xiaoping,Li, Xiangqian,et al. miR-125/Pokemon auto-circuit contributes to the progression of hepatocellular carcinoma[J]. TUMOR BIOLOGY,2016,37(1):511-519.
APA Kong, Jing.,Liu, Xiaoping.,Li, Xiangqian.,Wu, Jinsheng.,Wu, Ning.,...&Fang, Fang.(2016).miR-125/Pokemon auto-circuit contributes to the progression of hepatocellular carcinoma.TUMOR BIOLOGY,37(1),511-519.
MLA Kong, Jing,et al."miR-125/Pokemon auto-circuit contributes to the progression of hepatocellular carcinoma".TUMOR BIOLOGY 37.1(2016):511-519.
Files in This Item:
File Name/Size DocType Version Access License
miR-125Pokemon auto-(724KB)期刊论文出版稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Kong, Jing]'s Articles
[Liu, Xiaoping]'s Articles
[Li, Xiangqian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Kong, Jing]'s Articles
[Liu, Xiaoping]'s Articles
[Li, Xiangqian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Kong, Jing]'s Articles
[Liu, Xiaoping]'s Articles
[Li, Xiangqian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: miR-125Pokemon auto-circuit contributes to the progression of hepatocellular carcinoma.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.