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miR-125/Pokemon auto-circuit contributes to the progression of hepatocellular carcinoma
Kong, Jing1; Liu, Xiaoping1; Li, Xiangqian1; Wu, Jinsheng2; Wu, Ning3; Chen, Jun1; Fang, Fang1
2016
发表期刊TUMOR BIOLOGY
卷号37期号:1页码:511-519
文章类型Article
摘要Hepatocellular carcinoma (HCC) is a type of human malignant tumor occurring in hepatic tissues with high mortality. Patients benefit little from current therapeutic modalities, at least partially due to the lack of complete elucidation of molecular network regulating HCC. miR-125 and Pokemon are well-recognized tumor suppressor and oncogenes for HCC, respectively. However, the underlying mechanism by which the two genes exert their functions and the relationship between miR-125 and Pokemon is still unexplored yet. In this study, we found that there is an inverse association between miR-125 and Pokemon expression levels in HCC specimen and cell lines. Online database mining indicated that there are three putative mRNA recognition elements (MREs) of miR-125 within 3' untranslated region (3'UTR) of Pokemon. MREs of miR-125 confer the expression of luciferase with a miR-125-dependent fashion. The alteration in miR-125 abundance regulates the expression of Pokemon at both protein and mRNA levels. Overexpression of Pokemon is able to abrogate the inhibitory effect of miR-125 on HCC progression. Further study showed that Pokemon inhibits the expression of miR-125 by binding of recognition sites within its promoter. In conclusion, we found that there is an auto-regulatory circuit consisting of miR-125 and Pokemon, which promotes the progression of HCC and may be a promising therapeutic target in clinical HCC treatment.
关键词Mir-125 Pokemon Hcc
DOI10.1007/s13277-015-3596-7
收录类别SCI
语种英语
WOS记录号WOS:000374576200055
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/131045
专题实验海洋生物学重点实验室
作者单位1.Huaiyin Inst Technol, Fac Life Sci & Chem Engn, 1 Meicheng Rd East, Huaian 223003, Jiangsu, Peoples R China
2.Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Hepatopancreatobiliary Surg, 6 Beijing Rd West, Huaian 223300, Jiangsu, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
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Kong, Jing,Liu, Xiaoping,Li, Xiangqian,et al. miR-125/Pokemon auto-circuit contributes to the progression of hepatocellular carcinoma[J]. TUMOR BIOLOGY,2016,37(1):511-519.
APA Kong, Jing.,Liu, Xiaoping.,Li, Xiangqian.,Wu, Jinsheng.,Wu, Ning.,...&Fang, Fang.(2016).miR-125/Pokemon auto-circuit contributes to the progression of hepatocellular carcinoma.TUMOR BIOLOGY,37(1),511-519.
MLA Kong, Jing,et al."miR-125/Pokemon auto-circuit contributes to the progression of hepatocellular carcinoma".TUMOR BIOLOGY 37.1(2016):511-519.
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