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The inhibitory role of gamma-aminobutyric acid (GABA) on immunomodulation of Pacific oyster Crassostrea gigas
Li, Meijia1,3; Qiu, Limei1; Wang, Lingling1,2; Wang, Weilin1,3; Xin, Lusheng1,3; Li, Yiqun1,3; Liu, Zhaoqun1,3; Song, Linsheng2
2016-05-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
Volume52Pages:16-22
SubtypeArticle
Abstractgamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter to suppress the immune-mediated pro inflammatory reactions, and it has been used in the treatment of many inflammation-related diseases in vertebrates, while its immunomodulatory role in invertebrates has never been reported. In the present study, GABA was found to exist in the hemolymph of Pacific oyster Crassostrea gigas, and its concentration decreased slightly from 8.00 +/- 0.37 mu mol L-1 at normal condition to 7.73 +/- 0.15 mu mol L-1 at 6 h after LPS stimulation, and then increased to 9.34 +/- 0.15 mu mol L-1, 8.86 +/- 0.68 mu mol L-1 at 12 h and 48 h, respectively. After LPS stimulation, the mRNA expressions of pro-inflammatory cytokines (CgIL-17 and CgTNF) and immune effectors (CgSOD and CgBPI), and the protein expression of NOS increased significantly, and these increased trends were remarkably inhibited by GABA stimulation. At the same time, the phagocytosis rate and apoptosis rate of immunocytes also increased obviously after LPS stimulation, whereas the increase was repressed with the addition of GABA. The results collectively demonstrated that GABA was an indispensable inhibitory agent for both humoral and cellular immune response, which mainly functioned at the late phase of immune response to avoid the excess immune reactions and maintain the immune homeostasis. (C) 2016 Elsevier Ltd. All rights reserved.
KeywordCrassostrea Gigas Inhibitory Neurotransmitter Gamma-aminobutyric Acid Immunomodulation Immune Response
DOI10.1016/j.fsi.2016.03.015
Indexed BySCI
Language英语
WOS IDWOS:000375165200003
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/131034
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Dalian Ocean Univ, Key Lab Mariculture & Stock Enhancement North Chi, Minist Agr, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Meijia,Qiu, Limei,Wang, Lingling,et al. The inhibitory role of gamma-aminobutyric acid (GABA) on immunomodulation of Pacific oyster Crassostrea gigas[J]. FISH & SHELLFISH IMMUNOLOGY,2016,52:16-22.
APA Li, Meijia.,Qiu, Limei.,Wang, Lingling.,Wang, Weilin.,Xin, Lusheng.,...&Song, Linsheng.(2016).The inhibitory role of gamma-aminobutyric acid (GABA) on immunomodulation of Pacific oyster Crassostrea gigas.FISH & SHELLFISH IMMUNOLOGY,52,16-22.
MLA Li, Meijia,et al."The inhibitory role of gamma-aminobutyric acid (GABA) on immunomodulation of Pacific oyster Crassostrea gigas".FISH & SHELLFISH IMMUNOLOGY 52(2016):16-22.
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