Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| C5a of Cynoglossus semilaevis has anaphylatoxin-like properties and promotes antibacterial and antiviral defense | |
Li, Mo-fei1,2 ; Hu, Yong-hua1,2
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| 2016-07-01 | |
| Source Publication | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
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| Volume | 60Pages:139-148 |
| Subtype | Article |
| Abstract | Activation of the complement system leads to the cleavage of component factor C5 into C5a and C5b. C5a can induce chemotaxis and inflammatory responses in mammals. The function of C5a in fish is poorly understood. In this study, we report the identification and analysis of a C5 homologue, CsC5, from tongue sole (Cynoglossus semilaevis). CsC5 is composed of 1683 amino acid residues that include an anaphylatoxin homologous domain. Expression of CsC5 could be detected in a variety of tissues and was up regulated by bacterial or viral pathogen infection. Purified recombinant CsC5a (rCsC5a) could bind to peripheral blood leukocytes (PBL) and stimulate PBL chemotaxis, proliferation, respiratory burst, acid phosphatase activity, and phagocytosis. Tongue sole administered rCsC5a exhibited enhanced resistance against bacterial and viral infections. These results indicate that CsC5a is an anaphylatoxin with a role in innate immune defense against bacterial and viral infections. (C) 2016 Elsevier Ltd. All rights reserved. |
| Keyword | Complement Factor 5 Cynoglossus Semilaevis Peripheral Blood Leukocytes Antibacterial Antiviral |
| DOI | 10.1016/j.dci.2016.02.028 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000374613800014 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Version | 出版稿 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/131014 |
| Collection | 实验海洋生物学重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Li, Mo-fei,Hu, Yong-hua. C5a of Cynoglossus semilaevis has anaphylatoxin-like properties and promotes antibacterial and antiviral defense[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,60:139-148. |
| APA | Li, Mo-fei,&Hu, Yong-hua.(2016).C5a of Cynoglossus semilaevis has anaphylatoxin-like properties and promotes antibacterial and antiviral defense.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,60,139-148. |
| MLA | Li, Mo-fei,et al."C5a of Cynoglossus semilaevis has anaphylatoxin-like properties and promotes antibacterial and antiviral defense".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 60(2016):139-148. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| C5a of Cynoglossus s（4576KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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