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C5a of Cynoglossus semilaevis has anaphylatoxin-like properties and promotes antibacterial and antiviral defense
Li, Mo-fei1,2; Hu, Yong-hua1,2
2016-07-01
发表期刊DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号60页码:139-148
文章类型Article
摘要Activation of the complement system leads to the cleavage of component factor C5 into C5a and C5b. C5a can induce chemotaxis and inflammatory responses in mammals. The function of C5a in fish is poorly understood. In this study, we report the identification and analysis of a C5 homologue, CsC5, from tongue sole (Cynoglossus semilaevis). CsC5 is composed of 1683 amino acid residues that include an anaphylatoxin homologous domain. Expression of CsC5 could be detected in a variety of tissues and was up regulated by bacterial or viral pathogen infection. Purified recombinant CsC5a (rCsC5a) could bind to peripheral blood leukocytes (PBL) and stimulate PBL chemotaxis, proliferation, respiratory burst, acid phosphatase activity, and phagocytosis. Tongue sole administered rCsC5a exhibited enhanced resistance against bacterial and viral infections. These results indicate that CsC5a is an anaphylatoxin with a role in innate immune defense against bacterial and viral infections. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Complement Factor 5 Cynoglossus Semilaevis Peripheral Blood Leukocytes Antibacterial Antiviral
DOI10.1016/j.dci.2016.02.028
收录类别SCI
语种英语
WOS记录号WOS:000374613800014
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/131014
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
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Li, Mo-fei,Hu, Yong-hua. C5a of Cynoglossus semilaevis has anaphylatoxin-like properties and promotes antibacterial and antiviral defense[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,60:139-148.
APA Li, Mo-fei,&Hu, Yong-hua.(2016).C5a of Cynoglossus semilaevis has anaphylatoxin-like properties and promotes antibacterial and antiviral defense.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,60,139-148.
MLA Li, Mo-fei,et al."C5a of Cynoglossus semilaevis has anaphylatoxin-like properties and promotes antibacterial and antiviral defense".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 60(2016):139-148.
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