Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance

doi:10.3389/fmi0h.2010.00958

IOCAS-IR > 实验海洋生物学重点实验室

	Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance
	Xu, Gang-Ming
	2016-06-16
发表期刊	FRONTIERS IN MICROBIOLOGY
卷号	7
文章类型	Review
摘要	Cell cell communications, known as quorum sensing (QS) in bacteria, involve the signal molecules as chemical languages and the corresponding receptors as transcriptional regulators. In Gram-negative bacteria, orphan LuxR receptors recognize signals more than just acylhomoserine lactones, and modulate interspecies and interkingdom communications. Whereas, in the Gram-positive Streptomyces, pseudo gamma-butyrolactones (GBLs) receptors bind antibiotics other than GBL signals, and coordinate antibiotics biosynthesis. By interacting with structurally diverse molecules like antibiotics, the TetR family receptors regulate multidrug resistance (MDR) by controlling efflux pumps. Antibiotics at subinhibitory concentration may act as signal molecules; while QS signals also have antimicrobial activity at high concentration. Moreover, the QS and MDR systems may share the same exporters to transport molecules. Among these orphan LuxR, pseudo GBL receptors, and MDR regulators, although only with low sequence homology, they have some structure similarity and function correlation. Therefore, perhaps there might be evolutionary relationship and biological relevance between the regulatory systems of QS and MDR. Since the QS systems become new targets for antimicrobial strategy, it would expand our understanding about the evolutionary history of these regulatory systems.
关键词	Regulatory System Quorum Sensing Multidrug Resistance Transcriptional Regulator Signal Molecule
DOI	10.3389/fmi0h.2010.00958
收录类别	SCI
语种	英语
WOS记录号	WOS:000377853100001
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/130988
专题	实验海洋生物学重点实验室
作者单位	Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Xu, Gang-Ming. Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance[J]. FRONTIERS IN MICROBIOLOGY,2016,7.
APA	Xu, Gang-Ming.(2016).Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance.FRONTIERS IN MICROBIOLOGY,7.
MLA	Xu, Gang-Ming."Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance".FRONTIERS IN MICROBIOLOGY 7(2016).

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