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Understanding the Heat Shock Response in the Sea Cucumber Apostichopus japonicus, Using iTRAQ-Based Proteomics
Xu, Dongxue1,2; Sun, Lina1; Liu, Shilin1; Zhang, Libin1; Yang, Hongsheng1
2016-02-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume17Issue:2
SubtypeArticle
AbstractThe sea cucumber Apostichopus japonicus is exploited as a commercial species owing to their high nutritive and medicinal value. Recent high summer temperatures have caused high mortality rates in A. japonicus. In this study, we applied the isobaric tag for relative and absolute quantitation (iTRAQ) technique to investigate the global protein expression profile under an acute short-term (48 h) heat stress. In total, 3432 proteins were identified, and 127 proteins showed significant heat stress responses, with 61 upregulated proteins and 66 downregulated proteins. Our results suggest that heat stress influenced the expression of proteins involved in various biological processes, such as tissue protection and detoxification, lipid and amino acid metabolism, energy production and usage, transcription and translation, cell apoptosis, and cell proliferation. These findings provide a better understanding about the response and thermo-tolerance mechanisms of A. japonicus under heat stress.
KeywordApostichopus Japonicus Heat Stress Itraq Proteomics Analysis
DOI10.3390/ijms17020150
Indexed BySCI
Language英语
WOS IDWOS:000371830800089
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/126195
Collection海洋生态与环境科学重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Xu, Dongxue,Sun, Lina,Liu, Shilin,et al. Understanding the Heat Shock Response in the Sea Cucumber Apostichopus japonicus, Using iTRAQ-Based Proteomics[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016,17(2).
APA Xu, Dongxue,Sun, Lina,Liu, Shilin,Zhang, Libin,&Yang, Hongsheng.(2016).Understanding the Heat Shock Response in the Sea Cucumber Apostichopus japonicus, Using iTRAQ-Based Proteomics.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,17(2).
MLA Xu, Dongxue,et al."Understanding the Heat Shock Response in the Sea Cucumber Apostichopus japonicus, Using iTRAQ-Based Proteomics".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17.2(2016).
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