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| Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles | |
| Cao, Liang1; Huang, Wei1,2; Shan, Xiujuan1,3; Ye, Zhenjiang4; Dou, Shuozeng1; Dou, SZ (reprint author), Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China. | |
| 2012 | |
| 发表期刊 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
 |
| ISSN | 1382-6689 |
| 卷号 | 33期号:1页码:16-25 |
| 文章类型 | Article |
| 摘要 | This study investigated the accumulation of cadmium (0-8 mg Cd L-1) and its toxicological effects on oxidative stress biomarkers in different tissues of Japanese flounder juveniles. Following Cd exposure for 28 d, accumulation of Cd in fish was dose-dependent and tissue-specific, with the greatest accumulation in the liver, followed by the kidney, gill, and muscle. Although the gill and liver mounted active antioxidant responses at >= 4 mg L-1 Cd including a decrease in glutathione level and GST and GPx activities, the antioxidant response failed to prevent lipid peroxidation induction in these organs. In the kidney, increased GPx and GST activities and decreased SOD activity were observed in fish exposed to high Cd concentrations, but LPO levels did not significantly differ among the exposure concentrations. The gill was most sensitive to oxidative damage, followed by the liver; the kidney was the least affected tissue. (C) 2011 Published by Elsevier B.V. |
| 关键词 | Cd Antioxidants Lpo Accumulation Japanese Flounder |
| 学科领域 | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
| DOI | 10.1016/j.etap.2011.10.003 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000301876600003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/12450 |
| 专题 | 海洋生态与环境科学重点实验室 |
| 通讯作者 | Dou, SZ (reprint author), Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.State Ocean Adm, Lab Marine Ecosyst & Biogeochem, Inst Oceanog 2, Hangzhou 310012, Zhejiang, Peoples R China 3.Chinese Acad Fishery Sci, Yellow Sea Fishery Res Inst, Qingdao 266071, Peoples R China 4.Ocean Univ China, Fishery Coll, Qingdao 266003, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Cao, Liang,Huang, Wei,Shan, Xiujuan,et al. Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2012,33(1):16-25. |
| APA | Cao, Liang,Huang, Wei,Shan, Xiujuan,Ye, Zhenjiang,Dou, Shuozeng,&Dou, SZ .(2012).Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,33(1),16-25. |
| MLA | Cao, Liang,et al."Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 33.1(2012):16-25. |
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