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SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway
Zhao, Ying2; Chen, Huan2; Shang, Zhuo1; Jiao, Binghua2; Yuan, Bin2; Sun, Weizhang3; Wang, Bingui1; Miao, Mingyong2; Huang, Caiguo2; Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
2012-06-01
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume10Issue:6Pages:1345-1359
SubtypeArticle
AbstractA compound named SD118-xanthocillin X (1) (C18H12N2O2), isolated from Penicillium commune in a deep-sea sediment sample, has been shown to inhibit the growth of several cancer cell lines in vitro. In the present study, we employed a growth inhibition assay and apoptotic analysis to identify the biological effect and detailed mechanism of SD118-xanthocillin X (1) in human hepatocellular carcinoma (HepG2) cells. SD118-xanthocillin X (1) demonstrated a concentration-dependent inhibitory effect on the growth of HepG2 cells and caused slight cellular apoptosis and significantly induced autophagy. Autophagy was detected as early as 12 h by the conversion of microtubule-associated protein 1 light chain 3 (LC3-I) to LC3-II, following cleavage and lipid addition to LC3-I. The pharmacological autophagy inhibitor 3-methyladenine largely attenuates the growth inhibition and autophagic effect of SD118-xanthocillin X (1) in HepG2 cells. Our data also indicated that the autophagic effect of SD118-xanthocillin X (1) occurs via the down-regulation of the MEK/ERK signaling pathway and the up-regulated class III PI3K/Beclin 1 signaling pathway.
KeywordSd118-xanthocillin x (1) Autophagy Apoptosis Erk Beclin 1
Subject AreaChemistry, Medicinal
DOI10.3390/md10061345
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000305799800012
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/12376
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
3.Gen Hosp Chengdu Mil Command, PET Positron Emiss Computed Tomog Ctr, Chengdu 610083, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Ying,Chen, Huan,Shang, Zhuo,et al. SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway[J]. MARINE DRUGS,2012,10(6):1345-1359.
APA Zhao, Ying.,Chen, Huan.,Shang, Zhuo.,Jiao, Binghua.,Yuan, Bin.,...&Wang, BG .(2012).SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway.MARINE DRUGS,10(6),1345-1359.
MLA Zhao, Ying,et al."SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway".MARINE DRUGS 10.6(2012):1345-1359.
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