Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase

doi:10.1007/s00343-012-1241-5

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	Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase
	Liu Ming 1; Wei Jianteng 1,2; Wang Hui1,2 ; Ding Lili 1,2; Zhang Yuyan 1; Lin Xiukun 1,3; Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
	2012-09-01
发表期刊	CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN	0254-4059
卷号	30 期号:5 页码:724-730
文章类型	Article
摘要	Meretrix meretrix Linnaeus has long been used as traditional Chinese medicine in oriental medicine. The angiogentic activity of the extract of M. meretrix was investigated in this study, using human umbilical vein endothelial cells (HUVECs). Extract of M. meretrix Linnaeus (AFG-25) was prepared with acetone and ethanol precipitation, and further separated by Sephadex G-25 column. The results show that AFG-25 promoted proliferation, migration, and capillary-like tube formation in HUVECs, and in the presence of eNOS inhibitor NMA, the tube formation induced by AFG-25 is inhibited significantly. Moreover, AFG-25 could also promote the activation of endothelial nitric oxide synthase (eNOS) and the resultant elevation of nitric oxide (NO) production. The results suggested that M. meretrix contains active ingredients with angiogentic activity and eNOS/NO signal pathway is in part involved in the proangiogenesis effect induced by AFG-25.
关键词	Meretrix Meretrix Linnaeus Angiogenesis Nos Nitric Oxide (No)
学科领域	Limnology ; Oceanography
DOI	10.1007/s00343-012-1241-5
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000308357800002
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/12328
专题	实验海洋生物学重点实验室
通讯作者	Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Liu Ming,Wei Jianteng,Wang Hui,et al. Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2012,30(5):724-730.
APA	Liu Ming.,Wei Jianteng.,Wang Hui.,Ding Lili.,Zhang Yuyan.,...&Lin, XK .(2012).Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,30(5),724-730.
MLA	Liu Ming,et al."Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 30.5(2012):724-730.

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