Diverse Secondary Metabolites Produced by Marine-Derived Fungus Nigrospora sp MA75 on Various Culture Media

doi:10.1002/cbdv.201100216

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	Diverse Secondary Metabolites Produced by Marine-Derived Fungus Nigrospora sp MA75 on Various Culture Media
	Shang, Zhuo 1,2; Li, Xiao-Ming 1; Li, Chun-Shun 1; Wang, Bin-Gui1 ; Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
	2012-07-01
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	9 期号:7 页码:1338-1348
文章类型	Article
摘要	Bioassay-guided isolation of a fungal strain Nigrospora sp. MA75, an endophytic fungus obtained from the marine semi-mangrove plant Pongamia pinnata, which was fermented on three different culture media, resulted in the isolation and identification of seven known compounds, 2, 3, and 59, from a medium containing 3.5% NaCl, while a new compound, 2,3-didehydro-19a-hydroxy-14-epicochlioquinone B (10) was obtained from the medium containing 3.5% NaI. In addition, two new griseofulvin derivatives, 6-O-desmethyldechlorogriseofulvin (1) and 6'-hydroxygriseofulvin (4), were isolated and identified from the rice solid medium. Dechlorogriseofulvin (2) and griseofulvin (3) were the major components in fermentation extracts of all these culture media, while compounds 1 and 4, 5 and 6, and 10 were only present in the extract of respective culture medium. The structures of these compounds were elucidated by detailed spectroscopic analysis, and the absolute configuration of 1 was determined by CD measurement. Compounds 9 and 10 exhibited antibacterial activities toward five tested bacterial strains, while compounds 5, 6, and 8 selectively inhibited MRSA, E. coli, and S. epidermidis, and compound 3 showed moderate activity against V. mali and S. solani. Moreover, compound 10 potently inhibited the growth of MCF-7, SW1990, and SMMC7721 tumor cell lines with IC50 values of 4, 5, and 7 mu g/ml, respectively.
关键词	Marine Natural Products Fungi Nigrospora Species Antimicrobial Activity Cytotoxic Activity
学科领域	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
DOI	10.1002/cbdv.201100216
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000306313400010
引用统计	被引频次：54[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/12312
专题	实验海洋生物学重点实验室
通讯作者	Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Shang, Zhuo,Li, Xiao-Ming,Li, Chun-Shun,et al. Diverse Secondary Metabolites Produced by Marine-Derived Fungus Nigrospora sp MA75 on Various Culture Media[J]. CHEMISTRY & BIODIVERSITY,2012,9(7):1338-1348.
APA	Shang, Zhuo,Li, Xiao-Ming,Li, Chun-Shun,Wang, Bin-Gui,&Wang, BG .(2012).Diverse Secondary Metabolites Produced by Marine-Derived Fungus Nigrospora sp MA75 on Various Culture Media.CHEMISTRY & BIODIVERSITY,9(7),1338-1348.
MLA	Shang, Zhuo,et al."Diverse Secondary Metabolites Produced by Marine-Derived Fungus Nigrospora sp MA75 on Various Culture Media".CHEMISTRY & BIODIVERSITY 9.7(2012):1338-1348.

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