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A single immunoglobulin-domain IgSF protein from Sciaenops ocellatus regulates pathogen-induced immune response in a negative manner
Cheng, Shun-feng1,2; Hu, Yong-hua1; Sun, Bo-guang1; Zhang, Min1; Chi, Heng1; Sun, Li1; Sun, L (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.
2012-09-01
发表期刊DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
卷号38期号:1页码:117-127
文章类型Article
摘要The immunoglobulin superfamily (IgSF) is a large group of cell surface proteins that include various immunoregulatory receptors such as novel immune type receptors (NITRs), which are a family of diversified proteins found exclusively in body fish. In this study, we identified and analyzed an IgSF protein, SolgSF1, from red drum (Sciaenops oceans). SoIgSF1 is composed of 225 amino acid residues and moderately related to teleost NITRs. In silico analysis indicated that SoIgSF1 is a type I transmembrane glycoprotein and contains an N-terminal signal peptide sequence, a single extracellular immunoglobulin V domain, a transmembrane region, and a cytoplasmic region. However, unlike most NITRs, the cytoplasmic region of SoIgSF1 exhibits no consensus inhibitory or stimulatory signaling sequences but has two tyrosine-containing motifs that conform to the right-half sequence of the immunoreceptor tyrosine-based inhibitory motif (ITIM). Quantitative real time RT-PCR analysis showed that SolgSF1 expression occurred mainly in immune organs and was drastically induced by viral and bacterial infection. Immunofluorescence microscopy indicated that viral infection of head kidney (HK) leukocytes induced surface expression of SolgSF1, which was able to interact with antibodies against recombinant SoIgSF1. Antibody cross-linking of SolgSF1 on HK leukocytes inhibited the expression of immune relevant genes and promoted viral and bacterial infection. Taken together, these results indicate that SolgSF1, though lacking canonical intracellular signaling motifs, is involved in regulation of host immune response during pathogen infection possibly by functioning as a negative signaling receptor through a novel mechanism. (C) 2012 Elsevier Ltd. All rights reserved.
关键词Sciaenops Ocellatus Immunoglobulin Superfamily (Igsf) Novel Immune Type Receptors (Nitrs) Immunoregulatory Receptor
学科领域Immunology ; Zoology
DOI10.1016/j.dci.2012.04.012
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收录类别SCI
语种英语
WOS记录号WOS:000308271100013
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/12270
专题实验海洋生物学重点实验室
通讯作者Sun, L (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Agr Univ, Coll Anim Sci & Vet Med, Qingdao 266109, Peoples R China
第一作者单位实验海洋生物学重点实验室
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Cheng, Shun-feng,Hu, Yong-hua,Sun, Bo-guang,et al. A single immunoglobulin-domain IgSF protein from Sciaenops ocellatus regulates pathogen-induced immune response in a negative manner[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2012,38(1):117-127.
APA Cheng, Shun-feng.,Hu, Yong-hua.,Sun, Bo-guang.,Zhang, Min.,Chi, Heng.,...&Sun, L .(2012).A single immunoglobulin-domain IgSF protein from Sciaenops ocellatus regulates pathogen-induced immune response in a negative manner.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,38(1),117-127.
MLA Cheng, Shun-feng,et al."A single immunoglobulin-domain IgSF protein from Sciaenops ocellatus regulates pathogen-induced immune response in a negative manner".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 38.1(2012):117-127.
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