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Fucoidan Protects against Lipopolysaccharide-Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia
Cui, Yan-Qiu1,2; Jia, Yan-Jun1; Zhang, Ting3; Zhang, Quan-Bin4; Wang, Xiao-Min1; Wang, XM (reprint author), Capital Med Univ, Key Lab Neurodegenerat Dis, Minist Educ, 10 Xitoutiao, Beijing 100069, Peoples R China.
2012-10-01
发表期刊CNS NEUROSCIENCE & THERAPEUTICS
ISSN1755-5930
卷号18期号:10页码:827-833
文章类型Article
摘要Background Fucoidan, a sulfated polysaccharide extracted from brown algae, possesses potent antiinflammatory effects. Aims To examine the effect of fucoidan treatment on inflammation-mediated dopaminergic neuronal damage and its potential mechanisms. Methods Microglial activation and injury of dopaminergic neurons were induced by intranigral injection of lipopolysaccharide (LPS), and the effects of fucoidan treatment on animal behavior, microglial activation and survival ratio of dopaminergic neurons were investigated. We further observed the efficacy of fucoidan on tumor necrosis factor-alpha (TNF-a) and the production of reactive oxygen species (ROS) in LPS-activated primary microglia. Results Fucoidan significantly improved the behavioral manifestation, prevented the loss of dopaminergic neurons and inhibited the deleterious activation of microglia in the substantia nigra pars compacta of LPS-treated rats. Further in vitro experiments indicated that the excessive production of TNF-a and ROS in LPS-induced primary microglia were significantly inhibited by fucoidan administration. Conclusion This is the first study to demonstrate that fucoidan possesses neuroprotective effects on injured dopaminergic neurons in a LPS-induced animal model of Parkinson's disease. The mechanisms underlying these effects may include its potent down-regulation of intracellular ROS and subsequent proinflammatory cytokine release in LPS-activated microglia.
关键词Fucoidan Microglia Parkinson's Disease Reactive Oxygen Species Tumor Necrosis Factor-alpha
学科领域Neurosciences ; Pharmacology & Pharmacy
DOI10.1111/j.1755-5949.2012.00372.x
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收录类别SCI
语种英语
WOS记录号WOS:000309186000004
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被引频次:68[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/12225
专题海洋生物技术研发中心
通讯作者Wang, XM (reprint author), Capital Med Univ, Key Lab Neurodegenerat Dis, Minist Educ, 10 Xitoutiao, Beijing 100069, Peoples R China.
作者单位1.Capital Med Univ, Key Lab Neurodegenerat Dis, Minist Educ, Beijing 100069, Peoples R China
2.Capital Med Univ, Yanjing Med Coll, Beijing 100069, Peoples R China
3.Capital Med Univ, Dept Neurobiol, Beijing 100069, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
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Cui, Yan-Qiu,Jia, Yan-Jun,Zhang, Ting,et al. Fucoidan Protects against Lipopolysaccharide-Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia[J]. CNS NEUROSCIENCE & THERAPEUTICS,2012,18(10):827-833.
APA Cui, Yan-Qiu,Jia, Yan-Jun,Zhang, Ting,Zhang, Quan-Bin,Wang, Xiao-Min,&Wang, XM .(2012).Fucoidan Protects against Lipopolysaccharide-Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia.CNS NEUROSCIENCE & THERAPEUTICS,18(10),827-833.
MLA Cui, Yan-Qiu,et al."Fucoidan Protects against Lipopolysaccharide-Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia".CNS NEUROSCIENCE & THERAPEUTICS 18.10(2012):827-833.
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