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Cytotoxicity of the venom from the nematocysts of jellyfish Cyanea nozakii Kishinouye
Li Cuiping2; Li Pengcheng1; Feng Jinhua1; Li Rongfeng1; Yu Huahua1; Yu, HH (reprint author), Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.
2012-03-01
发表期刊TOXICOLOGY AND INDUSTRIAL HEALTH
ISSN0748-2337
卷号28期号:2页码:186-192
文章类型Article
摘要In this article, the cytotoxicity of the venom from the nematocysts of jellyfish Cyanea nozakii Kishinouye on human hepatoma cells (Bel-7402, SMMC-7721) and human colon cancer cells (H630) was investigated first. Of the three kinds of cells, the venom had the strongest cytotoxicity on H630 cells with the 50% lethal concentration (IC50) of 5.1 mu g/ml. However, the IC50 on Bel-7402 and SMMC-7721 was approximate 17.9 and 24.3 mu g/ml, respectively. The cytotoxicity of the venom was affected by pH, temperature and storage conditions. At the pH 4.5-8.5, the venom displayed obvious cytotoxicity and the percentage of survival was about 50%. When pre-incubated at temperatures over 60 degrees C for as short as 10 min, the percentage of survival sharply improved from 4.6% up to 80%. The venom was stored in a more stable condition at -80 degrees C and in lyophilized state compared to other storage conditions used in this study. Lactate dehydrogenase release assay performed on H630 cells indicated that exposure to the venom could result in damage to the cell membrane.
关键词Cytotoxicity Jellyfish Nematocysts Venom Cyanea Nozakii Kishinouye
学科领域Public, Environmental & Occupational Health ; Toxicology
DOI10.1177/0748233711410910
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000300222800013
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/12216
专题海洋生物技术研发中心
海洋环境工程技术研究发展中心
通讯作者Yu, HH (reprint author), Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Ocean Univ China, Qingdao Coll, Qingdao, Peoples R China
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Li Cuiping,Li Pengcheng,Feng Jinhua,et al. Cytotoxicity of the venom from the nematocysts of jellyfish Cyanea nozakii Kishinouye[J]. TOXICOLOGY AND INDUSTRIAL HEALTH,2012,28(2):186-192.
APA Li Cuiping,Li Pengcheng,Feng Jinhua,Li Rongfeng,Yu Huahua,&Yu, HH .(2012).Cytotoxicity of the venom from the nematocysts of jellyfish Cyanea nozakii Kishinouye.TOXICOLOGY AND INDUSTRIAL HEALTH,28(2),186-192.
MLA Li Cuiping,et al."Cytotoxicity of the venom from the nematocysts of jellyfish Cyanea nozakii Kishinouye".TOXICOLOGY AND INDUSTRIAL HEALTH 28.2(2012):186-192.
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