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A new ketosteroid from red alga Acanthophora spicifera
Shi Dayong; Guo Shuju; Fan Xiao
2011-05-01
发表期刊CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN0254-4059
卷号29期号:3页码:674-678
文章类型Article
摘要A new ketosteroid, along with six known steroids, was isolated from the ethanolic extracts of red alga Acanthophora spicifera (Vahl.) Boergesen. The structures, identified using chemical and spectroscopic methods including 2D NMR, were: (1) 22-hydroxy-5 alpha-cholest-3,6-dione, (2) 6-hydroxycholest-4-ene-3-one, (3) cholest-4-ene-3,6-dione, (4) cholest-5-ene-3 beta-ol, (5) 5 alpha-cholestane-3,6-dione, (6) beta-Sitosterol and (7) Saringosterol. The MTT method was used to test the cytotoxicity of the compounds against the human cancer cell lines, HCT-8, Bel-7402, BGC-823, A549 and HELA. Compounds 1, 2, 3 and 5 showed moderate cytotoxic activity against human cancer cell lines.; A new ketosteroid, along with six known steroids, was isolated from the ethanolic extracts of red alga Acanthophora spicifera (Vahl.) Boergesen. The structures, identified using chemical and spectroscopic methods including 2D NMR, were: (1) 22-hydroxy-5 alpha-cholest-3,6-dione, (2) 6-hydroxycholest-4-ene-3-one, (3) cholest-4-ene-3,6-dione, (4) cholest-5-ene-3 beta-ol, (5) 5 alpha-cholestane-3,6-dione, (6) beta-Sitosterol and (7) Saringosterol. The MTT method was used to test the cytotoxicity of the compounds against the human cancer cell lines, HCT-8, Bel-7402, BGC-823, A549 and HELA. Compounds 1, 2, 3 and 5 showed moderate cytotoxic activity against human cancer cell lines.
关键词Red Alga Acanthophora Spicifera (Vahl.) Boergesen Steroids Cytotoxic Activity
学科领域Marine & Freshwater Biology ; Oceanography
DOI10.1007/s00343-011-0183-7
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000292558100022
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/11993
专题海洋生物技术研发中心
作者单位Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
第一作者单位中国科学院海洋研究所
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Shi Dayong,Guo Shuju,Fan Xiao. A new ketosteroid from red alga Acanthophora spicifera[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2011,29(3):674-678.
APA Shi Dayong,Guo Shuju,&Fan Xiao.(2011).A new ketosteroid from red alga Acanthophora spicifera.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,29(3),674-678.
MLA Shi Dayong,et al."A new ketosteroid from red alga Acanthophora spicifera".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 29.3(2011):674-678.
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