Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S

doi:10.3390/md9010059

IOCAS-IR > 实验海洋生物学重点实验室

	Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S
	Gao, Shu-Shan 1,2; Li, Xiao-Ming 1; Du, Feng-Yu 1; Li, Chun-Shun 1; Proksch, Peter 3; Wang, Bin-Gui1
	2011
发表期刊	MARINE DRUGS
ISSN	1660-3397
卷号	9 期号:1 页码:59-70
文章类型	Article
摘要	Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from an unidentified marine red algal species of the genus Laurencia, displayed inhibitory activity against the growth of pathogen Alternaria brassicae in dual culture test. Chemical investigation of this fungal strain resulted in the isolation of four new (1-3 and 5) and one known (4) secondary metabolites. Their structures were identified as two polyketide derivatives penicitides A and B (1 and 2), two glycerol derivatives 2-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (3) and 1-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (4), and one monoterpene derivative penicimonoterpene (5). Penicitides A and B (1 and 2) feature a unique 10-hydroxy-or 7,10-dihydroxy-5,7-dimethylundecyl moiety substituting at C-5 of the alpha-tetrahydropyrone ring, which is not reported previously among natural products. Compound 5 displayed potent activity against the pathogen A. brassicae, while compound 1 exhibited moderate cytotoxic activity against the human hepatocellular liver carcinoma cell line.; Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from an unidentified marine red algal species of the genus Laurencia, displayed inhibitory activity against the growth of pathogen Alternaria brassicae in dual culture test. Chemical investigation of this fungal strain resulted in the isolation of four new (1-3 and 5) and one known (4) secondary metabolites. Their structures were identified as two polyketide derivatives penicitides A and B (1 and 2), two glycerol derivatives 2-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (3) and 1-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (4), and one monoterpene derivative penicimonoterpene (5). Penicitides A and B (1 and 2) feature a unique 10-hydroxy-or 7,10-dihydroxy-5,7-dimethylundecyl moiety substituting at C-5 of the alpha-tetrahydropyrone ring, which is not reported previously among natural products. Compound 5 displayed potent activity against the pathogen A. brassicae, while compound 1 exhibited moderate cytotoxic activity against the human hepatocellular liver carcinoma cell line.
关键词	Marine Endophyte Penicillium Chrysogenum Secondary Metabolites
学科领域	Pharmacology & Pharmacy
DOI	10.3390/md9010059
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000288892000004
引用统计	被引频次：75[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/11937
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Gao, Shu-Shan,Li, Xiao-Ming,Du, Feng-Yu,et al. Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S[J]. MARINE DRUGS,2011,9(1):59-70.
APA	Gao, Shu-Shan,Li, Xiao-Ming,Du, Feng-Yu,Li, Chun-Shun,Proksch, Peter,&Wang, Bin-Gui.(2011).Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S.MARINE DRUGS,9(1),59-70.
MLA	Gao, Shu-Shan,et al."Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S".MARINE DRUGS 9.1(2011):59-70.

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