Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S | |
Gao, Shu-Shan1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Proksch, Peter3; Wang, Bin-Gui1
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| 2011-05-15 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| ISSN | 0960-894X |
| 卷号 | 21期号:10页码:2894-2897 |
| 文章类型 | Article |
| 摘要 | Two new polyoxygenated steroids, namely, penicisteroids A and B (1 and 2), were obtained from the culture extract of Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from an unidentified marine red algal species of the genus Laurencia. In addition, seven known steroids (3-9) were also isolated and identified. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configuration for compound 1 was determined by application of the modified Mosher's method. Penicisteroid A (1), which is a structurally unique steroid having tetrahydroxy and C-16-acetoxy groups, displayed potent antifungal and cytotoxic activity in the preliminary bioassays. Preliminary structure-activity relationships are discussed. (C) 2011 Elsevier Ltd. All rights reserved.; Two new polyoxygenated steroids, namely, penicisteroids A and B (1 and 2), were obtained from the culture extract of Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from an unidentified marine red algal species of the genus Laurencia. In addition, seven known steroids (3-9) were also isolated and identified. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configuration for compound 1 was determined by application of the modified Mosher's method. Penicisteroid A (1), which is a structurally unique steroid having tetrahydroxy and C-16-acetoxy groups, displayed potent antifungal and cytotoxic activity in the preliminary bioassays. Preliminary structure-activity relationships are discussed. (C) 2011 Elsevier Ltd. All rights reserved. |
| 关键词 | Marine Endophyte Penicillium Chrysogenum Polyoxygenated Steroid Antifungal Activity Cytotoxic Activity |
| 学科领域 | Pharmacology & Pharmacy ; Chemistry |
| DOI | 10.1016/j.bmcl.2011.03.076 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000290024200021 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/11911 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Gao, Shu-Shan,Li, Xiao-Ming,Li, Chun-Shun,et al. Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(10):2894-2897. |
| APA | Gao, Shu-Shan,Li, Xiao-Ming,Li, Chun-Shun,Proksch, Peter,&Wang, Bin-Gui.(2011).Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(10),2894-2897. |
| MLA | Gao, Shu-Shan,et al."Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.10(2011):2894-2897. |
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