IOCAS-IR  > 实验海洋生物学重点实验室
Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula
Liu Xu1,2; Li Xiaoming1; Gao Lixin3; Cui Chuanming1,2; Li Chunshun1; Li Jia3; Wang Bingui1
2011-05-01
发表期刊CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN0254-4059
卷号29期号:3页码:686-690
文章类型Article
摘要Previously, we had characterized several structurally interesting brominated phenols from the marine red alga Symphyocladia latiuscula collected from various sites. However, Phytochemical investigations on this species collected from the Weihai coastline of Shandong Province remains blank. Therefore, we characterized the chemical constituents of individuals of this species collected from the region. Eight bromophenols were isolated and identified. Using detailed spectroscopic techniques and comparisons with published data, these compounds were identified as 2,3-dibromo-4,5-dihydroxybenzyl methyl ether (1), 3,5-dibromo-4-hydroxybenzoic acid (2), 2,3,6-tribromo-4,5-dihydroxymethylbenzene (3), 2,3,6-tribromo-4,5-dihydroxybenzaldehyde (4), 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether (5), bis(2,3,6-tribromo-4,5-dihydroxyphenyl) methane (6), 1,2-bis(2,3,6-tribromo-4,5-dihydroxyphenyl)-ethane (7), and 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)-pyrrolidin-2-one (8). Among these compounds, 1 and 2 were isolated for the first time from S. latiuscula. Each compound was evaluated on the ability to inhibit protein tyrosine phosphatase 1B (PTP1B), which is a potential therapeutic target in the treatment of type 2 diabetes. Bromophenols 5, 6, and 7 showed strong activities with IC(50) values of 3.9, 4.3, and 3.5 mu mol/L, respectively. This study provides further evidence that bromophenols are predominant among the chemical constituents of Symphyocladia, and that some of these compounds may be candidates for the development of anti-diabetes drugs.; Previously, we had characterized several structurally interesting brominated phenols from the marine red alga Symphyocladia latiuscula collected from various sites. However, Phytochemical investigations on this species collected from the Weihai coastline of Shandong Province remains blank. Therefore, we characterized the chemical constituents of individuals of this species collected from the region. Eight bromophenols were isolated and identified. Using detailed spectroscopic techniques and comparisons with published data, these compounds were identified as 2,3-dibromo-4,5-dihydroxybenzyl methyl ether (1), 3,5-dibromo-4-hydroxybenzoic acid (2), 2,3,6-tribromo-4,5-dihydroxymethylbenzene (3), 2,3,6-tribromo-4,5-dihydroxybenzaldehyde (4), 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether (5), bis(2,3,6-tribromo-4,5-dihydroxyphenyl) methane (6), 1,2-bis(2,3,6-tribromo-4,5-dihydroxyphenyl)-ethane (7), and 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)-pyrrolidin-2-one (8). Among these compounds, 1 and 2 were isolated for the first time from S. latiuscula. Each compound was evaluated on the ability to inhibit protein tyrosine phosphatase 1B (PTP1B), which is a potential therapeutic target in the treatment of type 2 diabetes. Bromophenols 5, 6, and 7 showed strong activities with IC(50) values of 3.9, 4.3, and 3.5 mu mol/L, respectively. This study provides further evidence that bromophenols are predominant among the chemical constituents of Symphyocladia, and that some of these compounds may be candidates for the development of anti-diabetes drugs.
关键词Marine Alga Rhodomelaceae Symphyocladia Latiuscula Bromophenol Protein Tyrosine Phosphatase 1b (Ptp1b)
学科领域Marine & Freshwater Biology ; Oceanography
DOI10.1007/s00343-011-0136-1
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000292558100024
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/11859
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
第一作者单位实验海洋生物学重点实验室
推荐引用方式
GB/T 7714
Liu Xu,Li Xiaoming,Gao Lixin,et al. Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2011,29(3):686-690.
APA Liu Xu.,Li Xiaoming.,Gao Lixin.,Cui Chuanming.,Li Chunshun.,...&Wang Bingui.(2011).Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,29(3),686-690.
MLA Liu Xu,et al."Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 29.3(2011):686-690.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Extraction and PTP1B(279KB) 限制开放--浏览
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu Xu]的文章
[Li Xiaoming]的文章
[Gao Lixin]的文章
百度学术
百度学术中相似的文章
[Liu Xu]的文章
[Li Xiaoming]的文章
[Gao Lixin]的文章
必应学术
必应学术中相似的文章
[Liu Xu]的文章
[Li Xiaoming]的文章
[Gao Lixin]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。