Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Conidiogenones H and I, Two New Diterpenes of Cyclopiane Class from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S | |
Gao, Shu-Shan1,2; Li, Xiao-Ming1; Zhang, Yi3; Li, Chun-Shun1; Wang, Bin-Gui1
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| 2011-09-01 | |
| 发表期刊 | CHEMISTRY & BIODIVERSITY
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| ISSN | 1612-1872 |
| 卷号 | 8期号:9页码:1748-1753 |
| 文章类型 | Article |
| 摘要 | Two new tetracyclic diterpenes of the rarely reported cyclopiane class, conidiogenones H and I (1 and 2, resp.), along with five related congeners, conidiogenones B - D and F (3-5 and 6, resp.) and conidiogenol (7), were characterized from the culture extracts of Penicillium chrysogenum QEN-24S, an endophytic fungus derived from an unidentified marine red algal species of the genus Laurencia. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The inhibitory activity of theses diterpenes against four bacteria and one pathogen fungus was evaluated. Conidiogenone B (3) showed potent activity against Methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas fluorescens, P. aeruginosa, and Staphylococcus epidermidis (each with a MIC value of 8 mu g/ml), while conidiogenol (7) showed obvious activity against P. fluorescens and S. epidermidis (each with a MIC value of 16 mu g/ml). This is the first report on antimicrobial activity of cyclopiane diterpenes.; Two new tetracyclic diterpenes of the rarely reported cyclopiane class, conidiogenones H and I (1 and 2, resp.), along with five related congeners, conidiogenones B - D and F (3-5 and 6, resp.) and conidiogenol (7), were characterized from the culture extracts of Penicillium chrysogenum QEN-24S, an endophytic fungus derived from an unidentified marine red algal species of the genus Laurencia. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The inhibitory activity of theses diterpenes against four bacteria and one pathogen fungus was evaluated. Conidiogenone B (3) showed potent activity against Methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas fluorescens, P. aeruginosa, and Staphylococcus epidermidis (each with a MIC value of 8 mu g/ml), while conidiogenol (7) showed obvious activity against P. fluorescens and S. epidermidis (each with a MIC value of 16 mu g/ml). This is the first report on antimicrobial activity of cyclopiane diterpenes. |
| 学科领域 | Biochemistry & Molecular Biology ; Chemistry |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000295257200011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/11817 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Dalian Jiaotong Univ, Sch Environm & Chem Engn, Dalian 116028, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Gao, Shu-Shan,Li, Xiao-Ming,Zhang, Yi,et al. Conidiogenones H and I, Two New Diterpenes of Cyclopiane Class from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S[J]. CHEMISTRY & BIODIVERSITY,2011,8(9):1748-1753. |
| APA | Gao, Shu-Shan,Li, Xiao-Ming,Zhang, Yi,Li, Chun-Shun,&Wang, Bin-Gui.(2011).Conidiogenones H and I, Two New Diterpenes of Cyclopiane Class from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S.CHEMISTRY & BIODIVERSITY,8(9),1748-1753. |
| MLA | Gao, Shu-Shan,et al."Conidiogenones H and I, Two New Diterpenes of Cyclopiane Class from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S".CHEMISTRY & BIODIVERSITY 8.9(2011):1748-1753. |
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