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Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection
Chi, Heng1,2; Sun, Li1,2
2016-03-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume56Issue:2016Pages:7-12
SubtypeArticle
AbstractNeutrophils constitute an essential part of the innate immune system. Recently, neutrophils have been found to produce a complex extracellular structure called neutrophil extracellular traps (NETs) that capture bacteria, fungi, and parasites. In fish, a few studies on NETs production have been reported, however, the function of fish NETs is unknown. In this study, we examined the ability of turbot (Scophthalmus maximus) neutrophils to produce NETs and investigated the effect of turbot NETs on bacterial infection. We found that upon lipopolysaccharides treatment, turbot head kidney neutrophils produced typical NETs structures that contained DNA and histones. Bacteria treatment also induced production of NETs, which in turn entrapped the bacterial cells and inhibited bacterial replication. Furthermore, when introduced into turbot, NETS-trapped bacteria exhibited significantly weakened ability of tissue dissemination and colonization. These results indicate for the first time that teleost NETs possess apparent antibacterial effect both in vitro and in vivo. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordNeutrophil Extracellular Trap Scophthalmus Maximus Antibacterial Innate Immune Defense
DOI10.1016/j.dci.2015.11.005
Indexed BySCI
Language英语
WOS IDWOS:000369196900002
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/112430
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Chi, Heng,Sun, Li. Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,56(2016):7-12.
APA Chi, Heng,&Sun, Li.(2016).Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,56(2016),7-12.
MLA Chi, Heng,et al."Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 56.2016(2016):7-12.
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