IOCAS-IR  > 实验海洋生物学重点实验室
Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection
Chi, Heng1,2; Sun, Li1,2
2016-03-01
发表期刊DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号56期号:2016页码:7-12
文章类型Article
摘要Neutrophils constitute an essential part of the innate immune system. Recently, neutrophils have been found to produce a complex extracellular structure called neutrophil extracellular traps (NETs) that capture bacteria, fungi, and parasites. In fish, a few studies on NETs production have been reported, however, the function of fish NETs is unknown. In this study, we examined the ability of turbot (Scophthalmus maximus) neutrophils to produce NETs and investigated the effect of turbot NETs on bacterial infection. We found that upon lipopolysaccharides treatment, turbot head kidney neutrophils produced typical NETs structures that contained DNA and histones. Bacteria treatment also induced production of NETs, which in turn entrapped the bacterial cells and inhibited bacterial replication. Furthermore, when introduced into turbot, NETS-trapped bacteria exhibited significantly weakened ability of tissue dissemination and colonization. These results indicate for the first time that teleost NETs possess apparent antibacterial effect both in vitro and in vivo. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Neutrophil Extracellular Trap Scophthalmus Maximus Antibacterial Innate Immune Defense
DOI10.1016/j.dci.2015.11.005
收录类别SCI
语种英语
WOS记录号WOS:000369196900002
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/112430
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
第一作者单位中国科学院海洋研究所
推荐引用方式
GB/T 7714
Chi, Heng,Sun, Li. Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,56(2016):7-12.
APA Chi, Heng,&Sun, Li.(2016).Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,56(2016),7-12.
MLA Chi, Heng,et al."Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 56.2016(2016):7-12.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Neutrophils of Scoph(1729KB)期刊论文出版稿限制开放CC BY-NC-SA浏览
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chi, Heng]的文章
[Sun, Li]的文章
百度学术
百度学术中相似的文章
[Chi, Heng]的文章
[Sun, Li]的文章
必应学术
必应学术中相似的文章
[Chi, Heng]的文章
[Sun, Li]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。